New approach to the synthesis of 1,3-chloroisothiocyanatoalkanes. synthesis of tetrahydro-1,3-thiazine-2-thiones and 2-alkylamino-5,6-dihydro-1,3-thiazines

摘要

A method was developed to prepare 1,3-chloroisothiocyanathoalkanes by reducing 1,3-isothiocyanato ketones using sodium borohydride at pH ～ 7 and subsequent treatment of the resultant 1,3-isothiocyanato alcohols with thionyl chloride. The reaction of 1,3-chloroisothiocyanatoalkanes with sodium hydrosulfide or amines gives substituted tetrahydro-1,3-thiazine-2-thiones or 2-amino-5,6-dihydro-1,3-thiazines.