首页> 外文期刊>ChemMedChem >Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement

【24h】

Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement

机译：五氟氟烷基的施用作为生物话代替代品

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Abstract > The success of fluorinated molecules in drug design has led medicinal chemists to search for new fluorine‐containing substituents. A major recently developed group is the pentafluorosulfanyl group. This group is stable under physiological conditions and displays unique physical and chemical properties. There are currently few synthetic methods to install the SF <sub>5</sub> group, yet efforts to integrate this group into lead optimization continue unabated. Typically, the SF <sub>5</sub> group has been used as a replacement for trifluoromethyl, tert ‐butyl, halogen, or nitro groups. In this review, the use of the SF <sub>5</sub> group as a bioisosteric replacement for each of these three functionalities is compared and contrasted across various groups of biologically active molecules. The organization and presentation of these data should be instructive to medicinal chemists considering to design synthetic strategies to access SF <sub>5</sub> ‐substituted molecules. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <标题类型=“main”>抽象</ title> > 药物设计中的氟化分子的成功使药用化学家寻找新的含氟取代基。最近发达的群体是五氟氟丁基。该组在生理条件下稳定，显示出独特的物理和化学性质。目前有很少的合成方法安装SF <sub> 5 </ sub> 小组，但努力将该组集成为铅优化继续不减。通常，SF <sub> 5 </ sub> 组已被用作三氟甲基的替代品， tert </ i> - 丁基，卤素或硝基。在本次审查中，使用SF <sub> 5 </ sub> 将组作为这些三种功能中的每一个的生物替代品进行比较，并在各种生物活性分子组中进行对比。这些数据的组织和介绍应该对药用化学家来说，考虑到设计综合策略来获得访问SF <sub> 5 </ sub> -substited分子。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16167/'>《ChemMedChem》</a> <b style="margin: 0 2px;">|</b><span>2017年第18期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sowaileh Munia F.&option=202" target="_blank" rel="nofollow">Sowaileh Munia F.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hazlitt Robert A.&option=202" target="_blank" rel="nofollow">Hazlitt Robert A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Colby David A.&option=202" target="_blank" rel="nofollow">Colby David A.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of BioMolecular SciencesUniversity of MississippiUniversity MS 38677 USA;</p> <p>Department of Developmental NeurobiologySt. Jude Children's Research HospitalMemphis TN 38105 USA;</p> <p>Department of BioMolecular SciencesUniversity of MississippiUniversity MS 38677 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/207.html" title="药学">药学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bioisosteres&option=203" rel="nofollow">bioisosteres;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=drug design&option=203" rel="nofollow">drug design;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fluorine&option=203" rel="nofollow">fluorine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nitro groups&option=203" rel="nofollow">nitro groups;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sulfur&option=203" rel="nofollow">sulfur;</a> </p> <div class="translation"> 机译：Bioisosteres;药物设计;氟;硝基;硫磺; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022088186.html">Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sowaileh Munia F.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sowaileh Munia F.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hazlitt Robert A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hazlitt Robert A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Colby David A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Colby David A. </a> <a href="/journal-foreign-16167/" target="_blank" rel="nofollow" class="tuijian_authcolor">ChemMedChem .</a> <span>2017</span><span>,第18期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：五氟氟烷基的施用作为生物话代替代品</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704028351434.html">Discovery of New Potent Positive Allosteric Modulators of Dopamine D-2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sampaio-Dias Ivo E.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sampaio-Dias Ivo E.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Reis-Mendes Ana&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Reis-Mendes Ana,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Costa Vera Marisa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Costa Vera Marisa,</a> <a href="/journal-foreign-35108/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Medicinal Chemistry .</a> <span>2021</span><span>,第9期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：发现多巴胺D-2受体的新有效阳性颠振调制剂：在Melanostatin神经肽中的脯氨酸生物替代品的见解</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020674021.html">Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A(2B) Adenosine Receptor Antagonists</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mallo-Abreu Ana&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mallo-Abreu Ana,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prieto-Diaz Ruben&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Prieto-Diaz Ruben,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jespers Willem&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jespers Willem,</a> <a href="/journal-foreign-35108/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Medicinal Chemistry .</a> <span>2020</span><span>,第14期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氮气步行方法探讨一系列有效A（2B）腺苷受体拮抗剂中的生物脑药替代品</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-258811_thesis/0705010883503.html">SAR STUDY OF GLYCOGEN PHOSPHORYLASE INHIBITORS: HETEROCYCLES AS BIOISOSTERIC AMIDE REPLACEMENTS IN N-ACYL-β-D-GLUCOPYRANOSYLAMINES AND N-ACYL-N'-β-D-GLUCOPYRANOSYL UREAS</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Toth M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Toth M.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Varga G. T.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Varga G. T.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Polyak M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Polyak M. </a> <a href="/conference-foreign-258811/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Carbohydrate Symposium .</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：SAR研究糖原磷酸化酶抑制剂：杂环作为N-酰基-β-D-吡喃葡萄糖胺和N-酰基-N'-β-D-吡喃葡萄糖脲替代的生物蛋白酶酰胺</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061845222.html">Syntheses and Applications of Trifluoromethyl- and Pentafluorosulfanyl-Containing Organic Molecules</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qing, Siyan.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qing, Siyan. </a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：三氟甲基和含五氟磺基的有机分子的合成及应用</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/0400012663.html">Structure–Activity Study of Bioisosteric Trifluoromethyland Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Celeste Alverez&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Celeste Alverez,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Michelle R. Arkin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Michelle R. Arkin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stacie L. Bulfer&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Stacie L. Bulfer,</a> <span>2015</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：生物等位三氟甲基的结构-活性研究ATPase p97和五氟硫烷基吲哚抑制剂</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000126644789.html">Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Celeste Alverez&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Celeste Alverez,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Michelle R. Arkin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Michelle R. Arkin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stacie L. Bulfer&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Stacie L. Bulfer,</a> <span>2015</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：AAA ATP酶P97的生物取代三氟甲基和五氟磺基吲哚抑制剂的结构 - 活性研究</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-catalysis_thesis/0201292120699.html">新型五氟苯铵三氟有机催化剂高效合成14-芳基(烷基)-14H-二苯并a,j呫吨类化合物和1,8-二氧代氧杂蒽衍生物(英文)</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Samad KHAKSAR&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Samad KHAKSAR</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nosratollah BEHZADI&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Nosratollah BEHZADI</a> <span> <a href="/journal-cn-28399/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 催化学报 </a> </span> <span> . 2012</span><span>,第6期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-xiamen-university-natural-science-edition_thesis/0201295395171.html">氟代烷基磺酰氟R_fSO_2F,一类新型的氟代试剂</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=严兆华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 严兆华</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=田伟生&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,田伟生</a> <span> <a href="/journal-cn-50807/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 厦门大学学报：自然科学版 </a> </span> <span> . 1999</span><span>,第S1期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chemical-journal-chinese-universities_thesis/0201231640307.html">氟代碳核苷类化合物的合成研究——N-烷基-5-甲酰胺基-1，2，4-氧杂二唑基-3-(4′-脱氧-4′-氟-β-L-吡喃型阿拉伯糖)的合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 程华</a> <span> <a href="/journal-cn-10958/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 高等学校化学学报 </a> </span> <span> . 1996</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-invention-patent_thesis/020123417210.html">新一代ODS替代品六氟-2-丁烯专利布局浅析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=罗霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 罗霞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张建君&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张建君</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=倪航&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,倪航</a> <span> <a href="/journal-cn-2677/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国发明与专利 </a> </span> <span> . 2016</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_asian-journal-ecotoxicology_thesis/0201216848850.html">PFOS潜在替代品全氟丁基磺酸钾对不同营养水平水生生物的毒性</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘敏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=殷浩文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,殷浩文</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈晓倩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈晓倩</a> <span> <a href="/journal-cn-9795/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生态毒理学报 </a> </span> <span> . 2013</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-31988_thesis/02022485515.html">氟代烷基碘酰氟R<,f>SO<,2>F,一类新型的氟代试剂</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=严兆华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 严兆华</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=田伟生&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,田伟生</a> <span> <a href="/conference-cn-31988/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第八届全国有机合成学术会议 </a> <span> <span> . 2000</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020316057903.html">二氟烷基化噁唑烷-2-亚胺的全新合成方法研究以及α,α,γ,γ-四氟-β-羟基酮和α-氟代苯乙酮的制备</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=鲍堃&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 鲍堃</a> <span> . 2020</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120111875838.html">一类新型血卟啉单氟代烷基双醚与氟代苯基烷基双醚衍生物及其在医药领域的应用</a> <b>[P]</b> . <span> 中国专利： CN111825685A </span> <span> . 2020-10-27</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120103593606.html">非均相钴催化制备烷基化或氟代烷基化、氯代烷基化、和氟代氯代烷基化化合物的方法</a> <b>[P]</b> . <span> 中国专利： CN110944965A </span> <span> . 2020-03-31</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130437798876.html">cycloalkyl derivatives with bioisosteric carboxylic acid groups, processes for their preparation and their application as a medicament</a> <b>[P]</b> . <span> 外国专利：  BRPI0407867A </span> <span> . 2006-03-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：具有生物等位羧酸基团的环烷基衍生物，其制备方法及其在药物中的应用 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130500863459.html">PENTAFLUOROSULFANYL-SUBSTITUTED AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF</a> <b>[P]</b> . <span> 外国专利：  EP3747865A4 </span> <span> . 2021-10-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：五氟磺酰基取代的酰胺化合物，其制备方法及其医学应用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130403442341.html">PENTAFLUOROSULFANYL-SUBSTITUTED AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF</a> <b>[P]</b> . <span> 外国专利：  WO2019144781A1 </span> <span> . 2019-08-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：五氟磺酰氟取代的酰胺化合物，其制备方法及其医学应用 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022088186','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);">回到顶部</a> </li> <li class="shouye"> <a href="/">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html">关于掌桥</a></li> <li><a href="/help/helpmap.html">资源导航</a></li> <li><a href="/help/helpguide.html">新手指南</a></li> <li><a href="/help/helpcenter.html">常见问题</a></li> <li><a href="/sitemap.html">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704022088186down" data-source="7," data-out-id="C7S8YGo6lWNCUP1k+pYxkA==," data-f-source-id="7" data-title="Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="16167" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.7"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>