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Advantages of API nanonization for drug development

机译:API纳米药物开发的优点

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摘要

A main cause of attrition in the drug development pathway is low solubility and bioavailability Nanonization can increase dissolution rates and improve bioavailability by increasing the surface area of APIs, The technique has multiple advantages over conventional techniques such as milling and spray-drying, with the latest technology capable of reducing the diameter of nanoparticles down to-Krnm.lHs reduced particle size can lead to enhanced drug development in multiple areas, including novel treatments for pulmonary, ocular and CNS disorders.
机译:药物发育途径中的疲劳性的主要原因是低溶解度,并且通过增加API的表面积来增加溶出速率并提高生物利用度,该技术具有多种优于铣削和喷雾干燥等铣削技术的优势,最新 能够降低纳米颗粒直径至-KRNM的技术降低粒度可能导致多个区域的药物发育,包括用于肺,眼和CNS疾病的新型治疗方法。

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