Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents

Kopruszinski Caroline Machado; Xie Jennifer Yanhua; Eyde Nathan Mackenzie; Remeniuk Bethany; Walter Sarah; Stratton Jennifer; Bigal Marcelo; Chichorro Juliana Geremias; Dodick David; Porreca Frank

首页> 外文期刊>Cephalalgia >Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents

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Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents

机译：通过啮齿动物中的降钙素基因相关肽抗体预防应力或一氧化氮供体诱导的药物过度使用头痛

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Objective: The objective of this study was the determination of the role of calcitonin gene-related peptide (CGRP) in the induction of medication overuse headache (MOH)-related migraine in an injury-free preclinical model.

机译：目的：本研究的目的是测定Calcitonin基因相关肽（CGRP）在无伤害临床前模型中的药物过度使用头痛（MOH）相关偏头痛中的作用。

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来源
《Cephalalgia》 |2017年第6期|共11页
作者
Kopruszinski Caroline Machado; Xie Jennifer Yanhua; Eyde Nathan Mackenzie; Remeniuk Bethany; Walter Sarah; Stratton Jennifer; Bigal Marcelo; Chichorro Juliana Geremias; Dodick David; Porreca Frank;
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作者单位

Univ Fed Parana Biol Sci Sect Dept Pharmacol Curitiba Parana Brazil;

Univ Arizona Coll Med Dept Pharmacol Tucson AZ 85724 USA;

Univ Arizona Coll Med Dept Pharmacol Tucson AZ 85724 USA;

Johns Hopkins Univ Sch Med Dept Psychiat &

Behav Sci Baltimore MD 21205 USA;

Antiva Biosci Inc San Francisco CA USA;

Teva Biol R&

D Redwood City CA USA;

Antiva Biosci Inc San Francisco CA USA;

Univ Fed Parana Biol Sci Sect Dept Pharmacol Curitiba Parana Brazil;

Mayo Clin Phoenix AZ USA;

Univ Arizona Coll Med Dept Pharmacol Tucson AZ 85724 USA;

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原文格式 PDF
正文语种 eng
中图分类诊断学;
关键词
Migraine; medication overuse headache; TEV48125; CGRP antibody; rats;

机译：偏头痛;药物过度使用头痛;tev48125;cgrp抗体;老鼠;

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专利

1. Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents [J] . Kopruszinski Caroline Machado, Xie Jennifer Yanhua, Eyde Nathan Mackenzie, Cephalalgia . 2017,第6期

机译：通过啮齿动物中的降钙素基因相关肽抗体预防应力或一氧化氮供体诱导的药物过度使用头痛
2. Calcitonin Gene-Related Peptide as An Endogenous Vasodilator: Immunoblockade Studies in Vivo with an Anti-Calcitonin Gene-Related Peptide Monoclonal Antibody and Its Fab′ Fragment [J] . Deborah A. Cook, Keith K. C. Tan, Morris J. Brown, Clinical Science . 1995,第6期

机译：降钙素基因相关肽作为内源性血管扩张剂：抗降钙素基因相关肽单克隆抗体及其Fab'片段的体内免疫阻断研究
3. EHMTI-0388. Levels of calcitonin-gene related peptide in medication overuse headache – a pilot study [J] . SB Munksgaard, E Frandsen, L Bendtsen, The journal of headache and pain . 2014,第1期

机译：EHMTI-0388。药物过度使用性头痛中降钙素基因相关肽的水平–一项初步研究
4. Prevention of Ethanol-inclucecl Gastric Mucosal Microcirculatory Disturbances by Mild Irritant Through the Actions of Calcitonin Gene-Related Peptide and Prostaglandin l2 in Rats [C] . Takeo Saeki, Takashi Ohno, Kazuhisa Kamata, Keio International Symposia for Life Sciences and Medicine . 2005

机译：通过钙蛋白基因相关肽和前列腺素L2的慢性刺激物通过轻度刺激物预防乙醇 - 增链型胃粘膜微循环干扰
5. Characterization of the gene for the calcitonin gene-related peptide (CGRP) receptor component protein (RCP), and generation of RCP +/- embryonic stem cells. [D] . Mnayer, Laila Omar. 2003

机译：降钙素基因相关肽（CGRP）受体成分蛋白（RCP）的基因表征以及RCP +/-胚胎干细胞的生成。
6. Letter to the editor: European headache federation guidelines on the use of monoclonal antibodies acting on the calcitonin gene-related peptide or its receptor for migraine prevention [O] . Daniel D. Mikol, Josefin Snellman 2019

机译：致编辑的信：欧洲头痛联合会指南关于使用与降钙素基因相关肽或其受体起作用的单克隆抗体预防偏头痛
7. Letter to the editor: European headache federation guidelines on the use of monoclonal antibodies acting on the calcitonin gene-related peptide or its receptor for migraine prevention [O] . Daniel D. Mikol, Josefin Snellman 2019

机译：致编辑的信：欧洲头痛联合会关于使用单克隆抗体作用的单克隆抗体，其在降钙素基因相关肽或其受体中进行偏头痛预防

Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents

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