偏头痛患者药物过度使用性头痛的相关因素及临床特点

摘要

Objective To explore the relevant factors and clinical features of patients with medication‐overuse mi‐graine.Methods 60 patients with medication‐overuse migraine (observation group) and another 60 patients with non‐drug ex‐cessive migraine (control group) were selected in the department of neurology in our hospital from August 2012 to August 2014.Visualanaloguescale(VAS)andtheMigrainedisabilityassessment(MIDAS)werecomparedinthetwogroup.Thecon‐tents included general data and the above clinical trial data ,which were imported into Excel 2013 and analyzed by SPSS 19.0. Results Patients'age ,disease duration of observation group compared with control group ,the difference had obviously statisti‐cal significance (P<0.01) ,and patients with a family history was statistically significant (P<0.05). The VAS score and MI‐DAS score in observation group were significantly higher than that in control group (P< 0.01).After stopping medication , 61.67% of the patients in observation group had withdrawal symptoms including irritability ,depression ,anxiety ,palpitation and so on ,and withdrawal symptoms disappeared within 3‐14d after giving symptomatic treatment timely.Conclusion The main factors of patients with medication‐overuse migraine related are age ,duration and family history.It is suggested that the levels of headache and disability are very high resulted from medication‐overuse migraine ,which could easily cause withdrawal symptoms after stopping the drug.%目的：探讨偏头痛患者药物过度使用性头痛的相关因素，并总结其临床特点。方法选取我院神经内科于2012‐08—2014‐08收治的60例药物过度使用性头痛患者以及60例非药物过度使用性头痛患者作为研究对象，对比观察2组患者的视觉模拟评分及偏头痛致残程度评分。结果观察组年龄、病程明显高于对照组（P＜0.01），有家族史患者明显多于对照组（P＜0.05）。观察组 VAS评分及 MIDAS总分明显高于对照组，差异具有统计学意义（P＜0.01）。观察组停药后61.67％的患者出现戒断症状，包括易激惹、近事遗忘、注意力分散、睡眠障碍、抑郁、焦虑、坐立不安、心悸、呕吐、恶心等，给予积极对症治疗于3～14 d内消失。结论偏头痛患者药物过度使用性头痛的相关因素主要有年龄、病程及家族史等，头痛程度以及致残程度较高，停用药物后极易引起戒断症状。