Selective One-Pot Two-Step C-C Bond Formation using Metal-Organic Frameworks with Mild Basicity as Heterogeneous Catalysts

摘要

Copper-ion-exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one-pot, two-step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity of multifunctional metal-organic framework catalysts through ion exchange with copper(II) cations allows the tandem C-C bond-forming process to be selectively directed towards the desired pharmaceutical intermediate.