A Divergent Duo: Palladium Catalyzed Carboamination in Enantioselective Desymmetrization and Regiodivergent Catalysis

摘要

We describe a regiodivergent synthesis of pseudo-C-2-symmetrical and pseudo-meso bis-indoline scaffolds from norbornadiene and substituted o-iodo-anilines. The Pd(0)/Josiphos system enables the highly regioselective catalyst controlled carboaminations required for the two step synthesis of the scaffolds.