Spontaneous Covalent Self‐Assembly of the <i >AzoarcusAzoarcus Ribozyme from Five Fragments

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Spontaneous Covalent Self‐Assembly of the AzoarcusAzoarcus Ribozyme from Five Fragments
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机译：来自五个碎片的自发性共价自组装 azoarcus 氮杂神话核酶
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Abstract > Spontaneous covalent assembly of short RNA fragments has been proposed as a plausible prebiotically relevant pathway to a self‐reproducing system. We previously showed that the Azoarcus group?I intron could self‐assemble from four RNA fragments. Here, we extended this fragmentation to five RNAs that averaged <40 nucleotides in length. We optimized this reaction and showed that a dehydration–rehydration sequence was the most effective means to date to shift the self‐assembly equilibrium from reactants to products. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >短RNA片段的自发性共价组装已被提出作为自我的合理纯粹相关的途径。 - 制作系统。我们以前表明 zooarcus </ i>组？I内含子可以从四个RNA片段自组装。在这里，我们将该碎片扩展至五个RNA，其长度平均<40个核苷酸。我们优化了该反应，并显示脱水再水化序列是迄今为止从反应物转移到产物的自组装平衡的最有效手段。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16039/'>《Chembiochem: A European journal of chemical biology》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共4页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jayathilaka Tharuka S.&option=202" target="_blank" rel="nofollow">Jayathilaka Tharuka S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lehman Niles&option=202" target="_blank" rel="nofollow">Lehman Niles;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryPortland State UniversityP.?O. Box 751 Portland OR 97207 USA;</p> <p>Department of ChemistryPortland State UniversityP.?O. Box 751 Portland OR 97207 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Azoarcus&option=203" rel="nofollow">Azoarcus;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=origins of life&option=203" rel="nofollow">origins of life;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=recombination&option=203" rel="nofollow">recombination;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ribozyme&option=203" rel="nofollow">ribozyme;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=RNA&option=203" rel="nofollow">RNA;</a> </p> <div class="translation"> 机译：azoarcus;生命的起源;重组;核酶;RNA; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022056421.html">Spontaneous Covalent Self‐Assembly of the <i >AzoarcusAzoarcus Ribozyme from Five Fragments</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jayathilaka Tharuka S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jayathilaka Tharuka S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lehman Niles&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lehman Niles </a> <a href="/journal-foreign-16039/" target="_blank" rel="nofollow" class="tuijian_authcolor">Chembiochem: A European journal of chemical biology .</a> <span>2018</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：来自五个碎片的自发性共价自组装 azoarcus </ i>氮杂神话核酶</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022454946.html">Formation of a water-mediated assembly of two neutral copper(II) Schiff base fragments with a Cu-2(NCS)(4) moiety: exploration of non-covalent C-H center dot center dot center dot pi(bimetallo ring) interactions</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roy Sourav&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Roy Sourav,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Drew Michael G. 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Spontaneous Covalent Self‐Assembly of the AzoarcusAzoarcus Ribozyme from Five Fragments

摘要