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首页> 外文期刊>Chembiochem: A European journal of chemical biology >Preparation of Cyclic Prodiginines by Mutasynthesis in Pseudomonas putidaPseudomonas putida KT2440
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Preparation of Cyclic Prodiginines by Mutasynthesis in Pseudomonas putidaPseudomonas putida KT2440

机译：在普赖达普赖达普赖达中制备循环潮素素的制备Pseudomonaspseudomonas putida Kt2440

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Abstract > Prodiginines are a group of naturally occurring pyrrole alkaloids produced by various microorganisms and known for their broad biological activities. The production of nature‐inspired cyclic prodiginines was enabled by combining organic synthesis with a mutasynthesis approach based on the GRAS (generally recognized as safe) certified host strain Pseudomonas putida KT2440. The newly prepared prodiginines exerted antimicrobial effects against relevant alternative biotechnological microbial hosts whereas P.?putida itself exhibited remarkable tolerance against all tested prodiginines, thus corroborating the bacterium's exceptional suitability as a mutasynthesis host for the production of these cytotoxic secondary metabolites. Moreover, the produced cyclic prodiginines proved to be autophagy modulators in human breast cancer cells. One promising cyclic prodiginine derivative stood out, being twice as potent as prodigiosin, the most prominent member of the prodiginine family, and its synthetic derivative obatoclax mesylate. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >生物素是一组由各种微生物产生的天然存在的吡咯生物碱，以其广泛的生物学而闻名活动。通过将有机合成与基于GRAS的更新方法组合（普遍认为是安全）的宿主菌株假单胞菌菌菌菌菌，通过将有机合成与蛋白合成方法相结合来实现自然启发的循环胰岛素的生产。新制备的ProDigines施加抗菌作用对相关的替代生物技术微生物宿主的抗菌作用，而 P.?putida </ i>本身表现出对所有测试的生物素的显着耐受性，从而证实了细菌的特殊适用性作为制备这些细胞毒性的蛋白质宿主次生代谢物。此外，所产生的循环生成素被证明是人乳腺癌细胞中的自噬调节剂。一个有前途的循环生殖素衍生物突出，是Prodigiosin，本科素家族最突出的成员的两倍，以及其合成衍生物Obatoclax甲磺酸盐。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16039/'>《Chembiochem: A European journal of chemical biology》</a> <b style="margin: 0 2px;">|</b><span>2018年第14期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klein Andreas Sebastian&option=202" target="_blank" rel="nofollow">Klein Andreas Sebastian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brass Hannah Ursula Clara&option=202" target="_blank" rel="nofollow">Brass Hannah Ursula Clara;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klebl David Paul&option=202" target="_blank" rel="nofollow">Klebl David Paul;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Classen Thomas&option=202" target="_blank" rel="nofollow">Classen Thomas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Loeschcke Anita&option=202" target="_blank" rel="nofollow">Loeschcke Anita;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Drepper Thomas&option=202" target="_blank" rel="nofollow">Drepper Thomas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sievers Sonja&option=202" target="_blank" rel="nofollow">Sievers Sonja;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jaeger Karl‐Erich&option=202" target="_blank" rel="nofollow">Jaeger Karl‐Erich;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pietruszka J?rg&option=202" target="_blank" rel="nofollow">Pietruszka J?rg;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Institute of Bioorganic ChemistryHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> <p>Institute of Bioorganic ChemistryHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> <p>Institute of Bioorganic ChemistryHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> <p>Insitute of Bio- and Geosciences (IBG-1): BiotechnologyForschungszentrum Jülich GmbHStetternicher Forst Building 15.8 52425 Jülich Germany;</p> <p>Institute of Molecular Enzyme TechnologyHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> <p>Institute of Molecular Enzyme TechnologyHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> <p>Compound Management and Screening Center (COMAS)Max Planck Institute of Molecular Physiology44202 Dortmund Germany;</p> <p>Institute of Molecular Enzyme TechnologyHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> <p>Institute of Bioorganic ChemistryHeinrich Heine University Düsseldorf located at Forschungszentrum JülichStetternicher Forst Building 15.8 52426 Jülich Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=alkaloids&option=203" rel="nofollow">alkaloids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antimicrobial activity&option=203" rel="nofollow">antimicrobial activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=autophagy modulation&option=203" rel="nofollow">autophagy modulation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mutasynthesis&option=203" rel="nofollow">mutasynthesis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=natural products&option=203" rel="nofollow">natural products;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=prodiginines&option=203" rel="nofollow">prodiginines;</a> </p> <div class="translation"> 机译：生物碱;抗菌活性;自噬调制;umas合成;天然产品;生物素; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022055999.html">Preparation of Cyclic Prodiginines by Mutasynthesis in <i >Pseudomonas putidaPseudomonas putida KT2440</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Klein Andreas Sebastian&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Klein Andreas Sebastian,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brass Hannah Ursula 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