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Identification of Candida albicans Candida albicansCandida albicans regulatory genes governing mucosal infection

机译：鉴定 念珠菌蛋白（Candida albicans Candida albicans 念珠菌念珠菌治疗基因治疗粘膜感染

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Abstract > The fungus <fc> <fi>Candida albicans</fi> </fc> thrives on a variety of human mucosae, yet the fungal determinants that contribute to fitness on these surfaces remain underexplored. Here, by screening a collection of <fc> <fi>C.?albicans</fi> </fc> deletion strains in a mouse model of oral infection (oropharyngeal candidiasis), we identify several novel regulatory genes that modulate the fitness of the fungus in this locale. We investigate in detail the interplay between the host mucosa and one of the identified mutants and establish that the <fc> <fi>C.?albicans</fi> </fc> transcription regulator <fi>CUP9</fi> is a key determinant of mucosal colonisation. Deletion of <fi>cup9</fi> resulted in the formation of more foci of colonisation and heightened persistence in infected tongues. Furthermore, the <fi>cup9</fi> mutant produced longer and denser filaments in the oral mucosa without eliciting an enhanced local immune response. Consistent with its role in oral colonisation, we show that <fi>CUP9</fi> 's top target of regulation is a major effector of <fi>Candida</fi> 's adherence to buccal cells. Finally, we establish that <fi>CUP9</fi> also governs the interplay of the fungus with vaginal epithelial cells and has a role in vaginal infections, another common mucosal disease associated with <fi>Candida</fi> . Thus, our findings reveal a mechanism whereby <fc> <fi>C.?albicans</fi> </fc> can regulate proliferation on mucosal surfaces. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > fungus <fc> <fi> candida albicans </ fi> </ fc>茁壮成长在各种人体粘膜上，对于在这些表面上有助于健康的真菌决定簇仍然是缺乏缺陷的。这里，通过筛选口服口服感染的小鼠模型中<FC> <FI> C.?ALBICANS </ FI> </ FC>缺失菌株的缺失菌株，我们鉴定了调节适应性的几种新型调节基因这个地方的真菌。我们详细探讨了宿主粘膜与鉴定突变体之一之间的相互作用，并确定<Fc> <Fi> C.? albicans </ Fi> </ Fc>转录调节器<Fi> Cup9 </ Fi>是一个粘膜定位的关键决定因素。删除<fi> cup9 </ fi>导致形成更多殖民化的焦点，并在感染的舌头上持续增长。此外，<FI> CUP9 </ FI>突变体在口腔粘膜中产生较长且密集细丝，而不引起增强的局部免疫应答。符合其在口腔殖民化中的作用，我们表明<fi> cup9 </ fi>的调节靶标是<fi>念珠菌的主要效应器，其粘附于颊细胞。最后，我们建立了<fi> cup9 </ fi>还可以治理用阴道上皮细胞的真菌的相互作用，并且在阴道感染中具有作用，另一种与<fi>念珠菌相关的常见粘膜疾病</ fi>。因此，我们的研究结果揭示了一种机制，即<Fc> <Fi> C.? albicans </ Fi> </ Fc>可以调节粘膜表面的增殖。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共17页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Meir Juliane&option=202" target="_blank" rel="nofollow">Meir Juliane;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hartmann Elena&option=202" target="_blank" rel="nofollow">Hartmann Elena;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eckstein Marie‐Therese&option=202" target="_blank" rel="nofollow">Eckstein Marie‐Therese;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guiducci Eva&option=202" target="_blank" rel="nofollow">Guiducci Eva;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kirchner Florian&option=202" target="_blank" rel="nofollow">Kirchner Florian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rosenwald Andreas&option=202" target="_blank" rel="nofollow">Rosenwald Andreas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LeibundGut‐Landmann Salomé&option=202" target="_blank" rel="nofollow">LeibundGut‐Landmann Salomé;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pérez J. Christian&option=202" target="_blank" rel="nofollow">Pérez J. Christian;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Interdisciplinary Center for Clinical ResearchUniversity Hospital WürzburgWürzburg Germany;</p> <p>Institute for PathologyUniversity WürzburgWürzburg Germany;</p> <p>Interdisciplinary Center for Clinical ResearchUniversity Hospital WürzburgWürzburg Germany;</p> <p>Section of Immunology Vetsuisse FacultyUniversity of ZürichZürich Switzerland;</p> <p>Section of Immunology Vetsuisse FacultyUniversity of ZürichZürich Switzerland;</p> <p>Institute for PathologyUniversity WürzburgWürzburg Germany;</p> <p>Section of Immunology Vetsuisse FacultyUniversity of ZürichZürich Switzerland;</p> <p>Interdisciplinary Center for Clinical ResearchUniversity Hospital WürzburgWürzburg Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Candida albicans&option=203" rel="nofollow">Candida albicans;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fungus–host interactions&option=203" rel="nofollow">fungus–host interactions;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mucosal infection&option=203" rel="nofollow">mucosal infection;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=regulator&option=203" rel="nofollow">regulator;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=transcription&option=203" rel="nofollow">transcription;</a> </p> <div class="translation"> 机译：念珠菌白醛;真菌 - 宿主相互作用;粘膜感染;调节剂;转录; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022032114.html">Identification of <fc > <fi>Candida albicans</fi> </fc> <fi >Candida albicans</fi>Candida albicans regulatory genes governing 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董翠兰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,董翠兰</a> <span> <a href="/conference-cn-13721/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 全国金属制品信息网第22届年会 </a> <span> <span> . 2010</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315225321.html">抗白念珠菌(Candida Albicans)中药材的筛选及复方MZ1711B抗菌功效与作用机制探究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邹金晶&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邹金晶</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120104527673.html">白色念珠菌(C.Albicans)中的必需基因及用该基因筛选抗真菌物质的方法</a> <b>[P]</b> . <span> 中国专利： CN1331753A </span> <span> . 2002-01-16</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061204321322.html">一种基于广电HFC网络的Wi-Fi实名认证方法</a> <b>[P]</b> . <span> 中国专利： CN108173848B </span> <span> . 2021.04.02</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130432894653.html">Nucleic acid and amino acid sequences of hemoglobin-response genes in <I>Candida albicans </I>and the use of reagents derived from these sequences in the diagnosis of disseminated <I>Candida albicans </I>infection</a> <b>[P]</b> . <span> 外国专利： <!-- 美国专利： --> US7332167B2 </span> <span> . 2008-02-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：白色念珠菌血红蛋白反应基因的核酸和氨基酸序列以及从这些序列衍生的试剂在诊断白色念珠菌传播中的应用 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130434058302.html">nucleic acid and amino acid sequences of induzierbaren - haemoglobin genes from candida albicans and the use of these sequences in the diagnosis of disseminated reagents candida albicans infection</a> <b>[P]</b> . <span> 外国专利： <!-- 德国专利： --> DE60035857D1 </span> <span> . 2007-09-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：念珠菌白色念珠菌-血红蛋白基因的核酸和氨基酸序列及其在诊断白色念珠菌传播试剂中的应用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130435070816.html">nucleic acid and amino acid sequences of induzierbaren - haemoglobin genes from candida albicans and the use of these sequences in the diagnosis of disseminated reagents candida albicans infection</a> <b>[P]</b> . <span> 外国专利： <!-- --> AT369426T </span> <span> . 2007-08-15</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> 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