TLR9 limits enteric antimicrobial responses and promotes microbiota‐based colonisation resistance during        <i >Citrobacter rodentiumCitrobacter rodentium        infection

Yang Hyungjun; Yu Hong B.; Bhinder Ganive; Ryz Natasha R.; Lee Julia; Yang Hong; Fotovati Abbas; Gibson Deanna L.; Turvey Stuart E.; Reid Gregor S.; Vallance Bruce A.

摘要

Abstract > Mammalian cells express an array of toll‐like receptors to detect and respond to microbial pathogens, including enteropathogenic and enterohemorrhagic <fc> <fi>E</fi> </fc> scherichia <fc> <fi>coli</fi> </fc> (EPEC and EHEC). These clinically important attaching and effacing (A/E) pathogens infect the apical surface of intestinal epithelial cells, causing inflammation as well as severe diarrheal disease. Because EPEC and EHEC are human‐specific, the related murine pathogen Citrobacter rodentium has been widely used to define how hosts defend against A/E pathogens. This study explored the role of TLR9, a receptor that recognises unmethylated CpG dinucleotides present in bacterial DNA, in promoting host defence against C.?rodentium . Infected Tlr9 ?/? mice suffered exaggerated intestinal damage and carried significantly higher (10–100?fold) pathogen burdens in their intestinal tissues as compared with wild type (WT) mice. C.?rodentium infection also induced increased antimicrobial responses, as well as hyperactivation of NF‐κB signalling in the intestines of Tlr9 ?/? mice. These changes were associated with accelerated depletion of the intestinal microbiota in Tlr9 ?/? mice as compared with WT mice. Notably, antibiotic‐based depletion of the gut microbiota in WT mice prior to infection increased their susceptibility to the levels seen in Tlr9 ?/? mice. Our results therefore indicate that TLR9 signalling suppresses intestinal antimicrobial responses, thereby promoting microbiota‐mediated colonisation resistance against </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘录</ title> >哺乳动物细胞表达一系列的收费量受体以检测和响应微生物病原体，包括肠致疗法和肠内鼠肠杆菌<FC> <FI> e </ FI> </ FC>施氏菌（Scherichia </ I> <FC> <Fi> Coli </ Fi> </ Fc>（EPEC和EHEC）。这些临床上重要的附着和抑制（A / E）病原体感染肠上皮细胞的顶端表面，引起炎症以及严重的腹泻病。因为EPEC和EHEC是人类特异性的，所以相关的小鼠病原体柠檬杆菌鼠/ i>已被广泛用于定义宿主如何防止A / E病原体。本研究探讨了TLR9的作用，一种识别细菌DNA中未甲基化的CPG二核苷酸的受体，在促进对I> C的宿主防御。感染 TLR9 </ i> ？/？</ sup>小鼠遭受夸张的肠损伤，与野生型（wt）小鼠相比，在其肠组织中携带显着更高（10-100倍）病原体负担。 C.?Rodentium </ i>感染还诱导增加的抗微生物反应，以及在 TLR9 的肠道中的NF-κB信号传导的血管活化α/α/αΩ 。与WT小鼠相比，这些变化与肠道微生物肠中的加速耗竭肠道微生物瘤相关有关。值得注意的是，在感染之前，WT小鼠中肠道微生物的基于抗生素微生物的耗尽增加了它们对 TLR9 α/α/α/αΩ的水平的敏感性。因此，我们的结果表明TLR9信号传导抑制肠道抗微生物反应，从而促进微生物液介导的殖民化抗性对抗1℃ </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第7期</span><b style="margin: 0 2px;">|</b><span>共19页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Hyungjun&option=202" target="_blank" rel="nofollow">Yang Hyungjun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Hong B.&option=202" target="_blank" rel="nofollow">Yu Hong B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bhinder Ganive&option=202" target="_blank" rel="nofollow">Bhinder Ganive;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ryz Natasha R.&option=202" target="_blank" rel="nofollow">Ryz Natasha R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Julia&option=202" target="_blank" rel="nofollow">Lee Julia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Hong&option=202" target="_blank" rel="nofollow">Yang Hong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fotovati Abbas&option=202" target="_blank" rel="nofollow">Fotovati Abbas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gibson Deanna L.&option=202" target="_blank" rel="nofollow">Gibson Deanna L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Turvey Stuart E.&option=202" target="_blank" rel="nofollow">Turvey Stuart E.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Reid Gregor S.&option=202" target="_blank" rel="nofollow">Reid Gregor S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vallance Bruce A.&option=202" target="_blank" rel="nofollow">Vallance Bruce A.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of Biology The Irving K. Barber School of Arts and SciencesUniversity of British ColumbiaKelowna British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> <p>Department of PediatricsBC Children's Hospital Research Institute and the University of British ColumbiaVancouver British Columbia Canada;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022032021.html">TLR9 limits enteric antimicrobial responses and promotes microbiota‐based colonisation resistance during <i >Citrobacter rodentiumCitrobacter rodentium infection</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Hyungjun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yang Hyungjun,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Hong B.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yu Hong B.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bhinder Ganive&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bhinder Ganive,</a> <a href="/journal-foreign-15891/" target="_blank" rel="nofollow" class="tuijian_authcolor">Cellular microbiology .</a> <span>2019</span><span>,第7期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：TLR9限制肠道抗菌反应，并在柠檬杆菌（Citrobacter rodentium）期间促进基于微生物群的定植抗性 - 柑橘菌毒素感染</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204118589594.html">Concurrent Infection with an Intestinal Helminth Parasite Impairs Host Resistance to Enteric Citrobacter rodentium and Enhances Citrobacter-Induced Colitis in Mice</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chien-Chang Chen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chien-Chang Chen,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Steve Louie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Steve Louie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Beth McCormick&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Beth McCormick,</a> <a href="/journal-foreign-20471/" target="_blank" rel="nofollow" class="tuijian_authcolor">Infection and immunity .</a> <span>2005</span><span>,第9期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肠道蠕虫寄生虫的并发感染会损害宿主对肠道柠檬酸杆菌的抵抗力，并增强小鼠柠檬酸杆菌诱导的结肠炎。</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204119179305.html">Impaired Resistance and Enhanced Pathology During Infection with a Noninvasive, Attaching-Effacing Enteric Bacterial Pathogen, Citrobacter rodentium, in Mice Lacking IL-12 or IFN-γ</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cameron P. 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TLR9 limits enteric antimicrobial responses and promotes microbiota‐based colonisation resistance during Citrobacter rodentiumCitrobacter rodentium infection

摘要