Enterohaemorrhagic        <fc >          <fi>Escherichia coli</fi>        </fc>          <fi >Escherichia coli</fi>Escherichia coli                produces outer membrane vesicles as an active defence system against antimicrobial peptide LL‐37

Urashima Akiko; Sanou Ayano; Yen Hilo; Tobe Toru

摘要

Abstract > Antimicrobial peptides (AMPs) are important components of the innate immune system. Enterohaemorrhagic <fc> <fi>Escherichia coli</fi> </fc> (EHEC), a food‐borne pathogen causing serious diarrheal diseases, must overcome attack by AMPs. Here, we show that resistance of EHEC against human cathelicidin LL‐37, a primary AMP, was enhanced by butyrate, which has been shown to act as a stimulant for the expression of virulence genes. The increase of resistance depended on the activation of the <fi>ompT</fi> gene, which encodes the outer membrane protease OmpT for LL‐37. The expression of the <fi>ompT</fi> gene was enhanced through the activation system for virulence genes. The increase in <fi>ompT</fi> expression did not result in an increase in OmpT protease in bacteria but in enhancement of the production of OmpT‐loaded outer membrane vesicles (OMVs), which primarily contributed to the increase in LL‐37‐resistance. Furthermore, a sublethal dosage of LL‐37 stimulated the production of OMVs. Finally, we showed that OMVs produced by OmpT‐positive strains protect the OmpT‐negative strain, which is susceptible to LL‐37 by itself more efficiently than OMVs from the <fi>ompT</fi> mutant. These results indicate that EHEC enhances the secretion of OmpT‐loaded OMVs in coordination with the activation of virulence genes during infection and blocks bacterial cell attack by LL‐37. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”> <标题类型=“main”>摘录</ title> >抗微生物肽（AMPs）是先天免疫系统的重要组成部分。 Enterohaemorrhagic <FC> <FI>大肠杆菌</ FI> </ FC>（EHEC），一种造成严重腹泻疾病的食物传播的病原体，必须克服AMPS的攻击。在这里，我们表明，通过丁酸丁酸盐增强了eHEC对人类植物疗法蛋白LL-37的阻力，这已被证明作为表达毒力基因的兴奋剂。抗性的增加依赖于激活<fi> ompt </ fi>基因，其为L1-37编码外膜蛋白酶Ompt。通过激活系统提高<fi> ompt </ fi>基因的表达通过用于毒力基因的活化系统。 <fi> ompt </ fi>表达的增加并未导致细菌中的ompt蛋白酶增加，但在加强ompt加载的外膜囊泡（OMV）的增强中，这主要导致LL-37的增加-反抗。此外，LL-37的亚致死剂量刺激了OMV的产生。最后，我们表明由OMPT阳性菌株产生的OMV保护OMPT阴性应变，其自身比来自<FI> OMPT </ FI>突变体的OMV更有效地更有效地易受LL-37。这些结果表明，通过在感染期间激活毒力基因的激活并阻断LL-37的细菌细胞攻击，EHEC在协调中增强了OMPT加载的OMVs的分泌。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Urashima Akiko&option=202" target="_blank" rel="nofollow">Urashima Akiko;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sanou Ayano&option=202" target="_blank" rel="nofollow">Sanou Ayano;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yen Hilo&option=202" target="_blank" rel="nofollow">Yen Hilo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tobe Toru&option=202" target="_blank" rel="nofollow">Tobe Toru;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Biomedical InformaticsOsaka University Graduate School of MedicineOsaka Japan;</p> <p>Department of Biomedical InformaticsOsaka University Graduate School of MedicineOsaka Japan;</p> <p>Department of Biomedical InformaticsOsaka University Graduate School of MedicineOsaka Japan;</p> <p>Department of Biomedical InformaticsOsaka University Graduate School of MedicineOsaka Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=butyrate&option=203" rel="nofollow">butyrate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LL‐37&option=203" rel="nofollow">LL‐37;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OmpT protease&option=203" rel="nofollow">OmpT protease;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OMVs&option=203" rel="nofollow">OMVs;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=secretion&option=203" rel="nofollow">secretion;</a> </p> <div class="translation"> 机译：丁酸盐;ll-37;ompt蛋白酶;omvs;分泌; 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target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 焦建军</a> <span> <a href="/journal-cn-14438/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 电子技术与软件工程 </a> </span> <span> . 2017</span><span>,第018期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_computer-systems-applications_thesis/0201241521305.html">基于K-Means和FCM的增强型Wi-Fi指纹定位策略</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈英</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=单文杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,单文杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨丰玉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨丰玉</a> <span> <a href="/journal-cn-8907/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 计算机系统应用 </a> </span> <span> . 2017</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-13721_thesis/02022967874.html">6×25Fi+FC钢丝绳用钢丝直径比的计算</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=曹玉德&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 曹玉德</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=武岳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,武岳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董翠兰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,董翠兰</a> <span> <a href="/conference-cn-13721/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 全国金属制品信息网第22届年会 </a> <span> <span> . 2010</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314513368.html">递呈胸膜肺炎放线杆菌GalT蛋白的大肠杆菌外膜囊泡免疫效果评价</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=祝壮&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 祝壮</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204321322.html">一种基于广电HFC网络的Wi-Fi实名认证方法</a> <b>[P]</b> . <span> 中国专利： CN108173848B </span> <span> . 2021.04.02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061202960866.html">使用NFC的WI-FI直连服务方法及其设备</a> <b>[P]</b> . <span> 中国专利： CN104956761B </span> <span> . 2018.08.10</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130400497340.html">GENE-THERAPEUTIC DNA-VECTOR BASED ON GENE-THERAPEUTIC DNA-VECTOR VTVAF17, CARRYING TARGET GENE SELECTED FROM GROUP OF GENES ANG, ANGPT1, VEGFA, FGF1, HIF1Α, HGF, SDF1, KLK4, PDGFC, PROK1, PROK2 TO INCREASE EXPRESSION LEVEL OF SAID TARGET GENES, METHOD FOR PRODUCTION AND USE THEREOF, STRAIN ESCHERICHIA COLI SCS110-AF/VTVAF17-ANG, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-ANGPT1, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-VEGFA, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-FGF1, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-HIF1Α, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-HGF, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-SDF1, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-KLK4, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-PDGFC, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-PROK1, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-PROK2, CARRYING GENE-THERAPEUTIC DNA VECTOR, METHOD FOR PRODUCTION THEREOF, METHOD FOR INDUSTRIAL PRODUCTION OF GENE-THERAPEUTIC DNA VECTOR</a> <b>[P]</b> . <span> 外国专利：  RU2730664C2 </span> <span> . 2020-08-24</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于基因治疗DNA载体VTVAF17的基因治疗DNA载体，携带选自基因ANG，ANGPT1，VEGFA，FGF1，HIF1α，HGF，SDF1，KLK4，PDGFC，PROK1，PROK2表达的靶基因所述的靶标基因，其生产和使用方法，应变大肠埃希氏菌SCS110-AF / VTVAF17-ANG或大肠埃希氏菌SCS110-AF / VTVAF17-ANGPT1或大肠埃希氏菌SCS110-AF / VTVAF17-VEGFA或大肠埃希氏菌SCS110-AF / VTVAF17-FGF1，或大肠埃希氏菌SCS110-AF / VTVAF17-HIF1A，或大肠埃希氏菌COLI SCS110-AF / VTVAF17-HGF，或大肠埃希氏菌SCS110-AF / VTVAF17-SDF1，或大肠埃希氏菌SCS110-AF / VTVAF17-KLK4，大肠埃希氏菌SCS110-AF / VTVAF17-PDGFC或大肠埃希氏菌SCS110-AF / VTVAF17-PROK2，携带基因-治疗性DNA载体，生产方法，工业生产方法-治疗性DNA载体 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130400537005.html">Gene therapeutic DNA vector based on VTvaf17 gene therapeutic DNA vector carrying a target gene selected from the group of genes ANG, ANGPT1, VEGFA, FGF1, HIF1α, HGF, SDF1, KLK4, PDGFC, PROK1, PROK2 to increase the expression level of these target genes, method its preparation and use, Escherichia coli strain SCS110-AF / VTvaf17-ANG or Escherichia coli SCS110-AF / VTvaf17-ANGPT1 or Escherichia coli SCS110-AF / VTvaf17-VEGFA or Escherichia coli SCS110-AF / VTvaf17-Fichia-SC110 AF / VTvaf17-HIF1α or Escherichia coli SCS110-AF / VTvaf17-HGF or Escherichia coli SCS110-AF / VTvaf17-SDF1 or Escherichia coli SCS110-AF / VTvaf17-KLK4 or Escherichia coli SCS110-AF / VTviFi10 SCF110 AF / VTvaf17-PROK1 or Escherichia coli SCS110-AF / VTvaf17-PROK2 carrying a gene therapy DNA vector, a method for its preparation, a method for the industrial production of a gene therapy DNA vector</a> <b>[P]</b> . <span> 外国专利：  RU2018147085A </span> <span> . 2020-06-29</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于VTvaf17基因治疗DNA载体的基因治疗DNA载体，其携带选自ANG，ANGPT1，VEGFA，FGF1，HIF1α，HGF，SDF1，KLK4，PDGFC，PROK1，PROK2的靶基因以增加这些靶标的表达水平基因，方法的制备和使用，大肠杆菌菌株SCS110-AF / VTvaf17-ANG或大肠杆菌SCS110-AF / VTvaf17-ANGPT1或大肠杆菌SCS110-AF / VTvaf17-VEGFA或大肠杆菌SCS110-AF / VTvaf17-Fichia-SC110 AF /VTvaf17-HIF1α或大肠杆菌SCS110-AF / VTvaf17-HGF或大肠杆菌SCS110-AF / VTvaf17-SDF1或大肠杆菌SCS110-AF / VTvaf17-KLK4或大肠杆菌SCS110-AF / VTviFi10 S1携带基因治疗DNA载体的大肠杆菌SCS110-AF / VTvaf17-PROK2，其制备方法，工业生产基因治疗DNA载体的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130400537445.html">Gene therapeutic DNA vector based on VTvaf17 gene therapeutic DNA vector, carrying the target gene selected from the group of genes NOS2, NOS3, VIP, KCNMA1, CGRP, to increase the expression level of these target genes, the method for its preparation and use, strain Escherichia coli SCS110-AF / VTvaf17-NOS2, or Escherichia coli SCS110-AF / VTvaf17-NOS3, or Escherichia coli SCS110-AF / VTvaf17-VIP, or Escherichia coli SCS110-AF / VTvaf17-KCNMA1, or Escherichia coli SCS110-AF / VTvaf17 gene therapy DNA vector, method for producing it, method for the industrial production of gene therapy DNA vector</a> <b>[P]</b> . <span> 外国专利：  RU2018145694A </span> <span> . 2020-06-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于VTvaf17基因治疗性DNA载体的基因治疗性DNA载体，其携带选自基因NOS2，NOS3，VIP，KCNMA1，CGRP的靶基因，以增加这些靶基因的表达水平，其制备方法和用途，菌株大肠杆菌SCS110-AF / VTvaf17-NOS2或大肠杆菌SCS110-AF / VTvaf17-NOS3或大肠杆菌SCS110-AF / VTvaf17-VIP或大肠杆菌SCS110-AF / VTvaf17-KCNCS1或Escherichia / VTvaf17基因治疗DNA载体，其生产方法，基因治疗DNA载体的工业化生产方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022031913','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div 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Enterohaemorrhagic Escherichia coli Escherichia coliEscherichia coli produces outer membrane vesicles as an active defence system against antimicrobial peptide LL‐37

摘要