The entry of        <i >SalmonellaSalmonella        in a distinct tight compartment revealed at high temporal and ultrastructural resolution

Fredlund Jennifer; Santos José Carlos; Stévenin Virginie; Weiner Allon; Latour‐Lambert Patricia; Rechav Katya; Mallet Adeline; Krijnse‐Locker Jacomine; Elbaum Michael; Enninga Jost

摘要

Abstract > <fi>Salmonella enterica</fi> induces membrane ruffling and genesis of macropinosomes during its interactions with epithelial cells. This is achieved through the type three secretion system‐1, which first mediates bacterial attachment to host cells and then injects bacterial effector proteins to alter host behaviour. Next, <fi>Salmonella</fi> enters into the targeted cell within an early membrane‐bound compartment that matures into a slow growing, replicative niche called the <fi>Salmonella</fi> Containing Vacuole (SCV). Alternatively, the pathogen disrupts the membrane of the early compartment and replicate at high rate in the cytosol. Here, we show that the <fi>in situ</fi> formed macropinosomes, which have been previously postulated to be relevant for the step of <fi>Salmonella</fi> entry, are key contributors for the formation of the mature intracellular niche of <fi>Salmonella</fi> . We first clarify the primary mode of type three secretion system‐1 induced <fi>Salmonella</fi> entry into epithelial cells by combining classical fluorescent microscopy with cutting edge large volume electron microscopy. We observed that <fi>Salmonella</fi> , similarly to <fi>Shigella</fi> , enters epithelial cells inside tight vacuoles rather than in large macropinosomes. We next apply this technology to visualise rupturing <fi>Salmonella</fi> containing compartments, and we use extended time‐lapse microscopy to establish early markers that define which <fi>Salmonella</fi> will eventually hyper replicate. We show that at later infection stages, SCVs harbouring replicating <fi>Salmonella</fi> have previously fused with the <fi>in situ</fi> formed macropinosom </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“En”> <Title Type =“Main”> Abstract </ Title> > <Fi> Salmonella enterica </ Fi>在其相互作用期间诱导膜荷叶林和Macropinosomes的成因上皮细胞。这是通过三种分泌系统-1实现的，首先将细菌附着介导给宿主细胞，然后注射细菌效应蛋白以改变宿主行为。接下来，<fi>沙门氏菌进入靶膜的侧腔内的靶细胞中，该隔室成熟成缓慢的生长，复制性含有液泡（SCV）的<FI>沙门氏菌/固醇液。或者，病原体破坏早期隔室的膜并以高速率在细胞溶胶中复制。在这里，我们表明<fi>原位</ fi>形成的macropinosomes，其先前假设与<fi> salmonella </ fi>入口的步骤相关，是形成成熟细胞内的主要贡献者<fi>沙门氏菌的利基</ fi>。我们首先通过将经典荧光显微镜与切削刃大容量电子显微镜结合，阐明三种分泌系统-1诱导的<fi>沙门氏菌的主要模式进入上皮细胞。我们观察到<fi>沙门氏菌</ fi>类似于<fi> shigella </ fi>，进入紧密液泡内的上皮细胞而不是大的macopinosomes。我们接下来应用该技术来可视化含有隔室的破裂<fi>沙门氏菌，并且我们使用延长的延时显微镜来建立定义哪些<fi>沙门氏菌</ fi>最终过度复制的早期标记。我们表明，在以后的感染阶段，SCVS遍历复制<fi>沙门氏菌</ fi>以前与<fi>原位融合了</ fi>形成的macropinosom </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology 》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b> <span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fredlund Jennifer&option=202" target="_blank" rel="nofollow">Fredlund Jennifer;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Santos José Carlos&option=202" target="_blank" rel="nofollow">Santos José Carlos;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stévenin Virginie&option=202" target="_blank" rel="nofollow">Stévenin Virginie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Weiner Allon&option=202" target="_blank" rel="nofollow">Weiner Allon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Latour‐Lambert Patricia&option=202" target="_blank" rel="nofollow">Latour‐Lambert Patricia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rechav Katya&option=202" target="_blank" rel="nofollow">Rechav Katya;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mallet Adeline&option=202" target="_blank" rel="nofollow">Mallet Adeline;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krijnse‐Locker Jacomine&option=202" target="_blank" rel="nofollow">Krijnse‐Locker Jacomine;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Elbaum Michael&option=202" target="_blank" rel="nofollow">Elbaum Michael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Enninga Jost&option=202" target="_blank" rel="nofollow">Enninga Jost;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Unité “Dynamique des interactions h?te‐pathogène”Institut PasteurParis France;</p> <p>Unité “Dynamique des interactions h?te‐pathogène”Institut PasteurParis France;</p> <p>Unité “Dynamique des interactions h?te‐pathogène”Institut PasteurParis France;</p> <p>Unité “Dynamique des interactions h?te‐pathogène”Institut PasteurParis France;</p> <p>Unité “Dynamique des interactions h?te‐pathogène”Institut PasteurParis France;</p> <p>Department of InterfacesThe Weizmann Institute of SciencesRehovot Israel;</p> <p>“Ultrapole”Institut PasteurParis France;</p> <p>“Ultrapole”Institut PasteurParis France;</p> <p>Department of InterfacesThe Weizmann Institute of SciencesRehovot Israel;</p> <p>Unité “Dynamique des interactions h?te‐pathogène”Institut PasteurParis France;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=correlative light electron mciroscopy&option=203" rel="nofollow">correlative light electron mciroscopy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=host cell invasion&option=203" rel="nofollow">host cell invasion;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intracellular trafficking&option=203" rel="nofollow">intracellular trafficking;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=macropinosomes&option=203" rel="nofollow">macropinosomes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Salmonella&option=203" rel="nofollow">Salmonella;</a> </p> <div class="translation"> 机译：相关光电子麦考镜;宿主细胞侵袭;细胞内贩运;Macropinosomes;沙门氏菌; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div 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The entry of SalmonellaSalmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution

摘要