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首页> 外文期刊>Cellular microbiology >Extracellular vesicles from early stage Plasmodium falciparum Plasmodium falciparumPlasmodium falciparum ‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes
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Extracellular vesicles from early stage Plasmodium falciparum Plasmodium falciparumPlasmodium falciparum ‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

机译：来自早期阶段的细胞外囊 疟原虫（Falciparum） 疟原虫疟原虫 - 疟原虫 - 血浆 - 血浆 - 血浆 - 血浆 - 植物的红细胞含有pfemp1并诱导人单核细胞的转录变化

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Abstract > Pathogens can release extracellular vesicles (EVs) for cell–cell communication and host modulation. EVs from <fi>Plasmodium falciparum</fi> , the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late‐stage parasite‐infected RBC (iRBC‐EVs) are immunostimulatory and affect endothelial cell permeability, but little is known about EVs from early stage iRBC. We detected the parasite virulence factor PfEMP1, which is responsible for iRBC adherence and a major contributor to disease severity, in EVs, only up to 12‐hr post‐RBC invasion. Furthermore, using PfEMP1 transport knockout parasites, we determined that EVs originated from inside the iRBC rather than the iRBC surface. Proteomic analysis detected 101 parasite and 178 human proteins in iRBC‐EVs. Primary human monocytes stimulated with iRBC‐EVs released low levels of inflammatory cytokines and showed transcriptomic changes. Stimulation with iRBC‐EVs from PfEMP1 knockout parasites induced more gene expression changes and affected pathways involved in defence response, stress response, and response to cytokines, suggesting a novel function of PfEMP1 when present in EVs. We show for the first time the presence of PfEMP1 in early stage <fi>P.?falciparum</fi> iRBC‐EVs and the effects of these EVs on primary human monocytes, uncovering a new mechanism of potential parasite pathogenesis and host interaction. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <title类型=“main”>抽象</ title> > Pathongens可以释放细胞单元通信和主机调制的extracellular囊泡（EV。来自<FI>疟原虫的EVS </ FI>，最致命的疟疾寄生虫物种，可以在寄生虫之间转移耐药基因。来自晚期寄生虫感染的RBC（IRBC-EV）的EVS是免疫刺激性的，并且影响内皮细胞渗透性，但是从早期IRBC的EVS少了解。我们检测到寄生虫毒力因子pfemp1，它负责伊博尔邦克遵守和疾病严重程度的主要贡献者，只有12人的RBC侵袭。此外，使用PFEMP1运输敲除寄生虫，我们确定EVS来自IRBC内部而不是IRBC表面。蛋白质组学分析检测到IRBC-EVS中的101个寄生虫和178例人蛋白。用IRBC-EV刺激的原发性人单核细胞释放出低水平的炎性细胞因子并显示出转录组的变化。来自PFEMP1敲除寄生虫的刺激诱导了更多基因表达变化和受到防御反应，应激反应和对细胞因子的反应中的受影响的途径，表明在EVS中存在PFEMP1的新功能。我们首次展示早期PFEMP1的存在<FI> P.?Falcarum </ Fi> IRBC-EV和这些EVS对原发性人机的影响，揭示了潜在寄生虫发病机制和宿主相互作用的新机制。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共18页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sampaio Natália G.&option=202" target="_blank" rel="nofollow">Sampaio Natália G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Emery Samantha J.&option=202" target="_blank" rel="nofollow">Emery Samantha J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Garnham Alexandra L.&option=202" target="_blank" rel="nofollow">Garnham Alexandra L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tan Qiao Y.&option=202" target="_blank" rel="nofollow">Tan Qiao Y.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sisquella Xavier&option=202" target="_blank" rel="nofollow">Sisquella Xavier;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pimentel Matthew A.&option=202" target="_blank" rel="nofollow">Pimentel Matthew A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jex Aaron R.&option=202" target="_blank" rel="nofollow">Jex Aaron R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Regev‐Rudzki Neta&option=202" target="_blank" rel="nofollow">Regev‐Rudzki Neta;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schofield Louis&option=202" target="_blank" rel="nofollow">Schofield Louis;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eriksson Emily M.&option=202" target="_blank" rel="nofollow">Eriksson Emily M.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Population Health and Immunity DivisionWalter and Eliza Hall Institute of Medical ResearchParkville Victoria Australia;</p> <p>Population Health and Immunity DivisionWalter and Eliza Hall Institute of Medical ResearchParkville Victoria Australia;</p> <p>Department of Medical BiologyUniversity of MelbourneParkville Victoria Australia;</p> <p>Population Health and Immunity DivisionWalter and Eliza Hall Institute of Medical ResearchParkville Victoria Australia;</p> <p>Department of Medical BiologyUniversity of MelbourneParkville Victoria Australia;</p> <p>Department of Medical BiologyUniversity of MelbourneParkville Victoria Australia;</p> <p>Population Health and Immunity DivisionWalter and Eliza Hall Institute of Medical ResearchParkville Victoria Australia;</p> <p>Department of Medical BiologyUniversity of MelbourneParkville Victoria Australia;</p> <p>Population Health and Immunity DivisionWalter and Eliza Hall Institute of Medical ResearchParkville Victoria Australia;</p> <p>Population Health and Immunity DivisionWalter and Eliza Hall Institute of Medical ResearchParkville Victoria Australia;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=diseases&option=203" rel="nofollow">diseases;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=extracellular vesicles&option=203" rel="nofollow">extracellular vesicles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=immunology&option=203" rel="nofollow">immunology;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=infection&option=203" rel="nofollow">infection;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=proteomics&option=203" rel="nofollow">proteomics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=transcriptomics&option=203" rel="nofollow">transcriptomics;</a> </p> <div class="translation"> 机译：疾病;细胞外囊;免疫学;感染;蛋白质组学;转录组织; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022031755.html">Extracellular vesicles from early stage <fc > <fi>Plasmodium falciparum</fi> </fc> <fi >Plasmodium falciparum</fi>Plasmodium falciparum ‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sampaio Natália G.&option=202" target="_blank" rel="nofollow" class="tuijian_auth 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