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Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity?

机译:运动诱导的肿瘤生理微环境调节改善抗肿瘤免疫力吗?

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摘要

The immune system plays an important role in controlling cancer growth. However, cancers evolve to evade immune detection. Immune tolerance and active immune suppression results in unchecked cancer growth and progression. A major contributor to immune tolerance is the tumor physiologic microenvironment, which includes hypoxia, hypoglucosis, lactosis, and reduced pH. Preclinical and human studies suggest that exercise elicits mobilization of leukocytes into circulation (also known as "exercise-induced leukocytosis"), especially cytotoxic T cells and natural killer cells. However, the tumor physiologic microenvironment presents a significant barrier for these cells to enter the tumor and, once there, properly function. We hypothesize that the effect of exercise on the immune system's ability to control cancer growth is linked to how exercise affects the tumor physiologic microenvironment. Normalization of the microenvironment by exercise may promote more efficient innate and adaptive immunity within the tumor. This review summarizes the current literature supporting this hypothesis.
机译:免疫系统在控制癌症生长方面发挥着重要作用。然而,癌症演变以逃避免疫检测。免疫耐受性和活性免疫抑制导致未经检查的癌症生长和进展。对免疫耐受的主要贡献者是肿瘤生理学微环境,其包括缺氧,低葡葡萄杆菌,泌乳病和降低pH。临床前和人类研究表明,运动引发了将白细胞的血液流入循环(也称为“运动诱导的白细胞增多”),特别是细胞毒性T细胞和天然杀伤细胞。然而,肿瘤生理学微环境对于这些细胞进入肿瘤并且一旦存在妥善发挥作用,具有显着的屏障。我们假设运动对免疫系统控制癌症生长能力的影响与运动如何影响肿瘤生理微环境有关。通过运动的微环境正常化可以促进肿瘤内更有效的先天和适应性免疫。本综述总结了支持这一假设的当前文献。

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