Management Strategies and Outcomes for Hyponatremia in Cirrhosis in the Hyponatremia Registry

摘要

Dilutional hyponatremia (HN) is a frequent consequence of severe portal hypertension in cirrhosis. It is the result of severe vasodilation, leading to increased arginine vasopressin (AVP) release and consequent water retention [1, 2]. HN is especially common in the hospitalized patient [3] and is associated with severe ascites, hepatic encephalopathy (HE), and impaired renal function. In a retrospective study of 20,000 patients, HN was predictive of worsening disease, mortality, a higher 30-day readmission rate [4], and a 1.74-day increase in average hospital length of stay (LOS).