Xenobiotics and their impact on metabolic diseases

摘要

Metabolic diseases are a growing public health issue. Many pollutants or food contaminants are suspected of contributing to the emergence of these diseases through their action as endocrine disrupters or as obesogens. In this review, we will describe the many pathways of entry of these xenobiotics, from production to food consumption, as well as their various modes of action. We will deal with molecules as diverse as dioxins, polycyclic aromatic hydrocarbons, acrylamide, bisphenols, phthalates as well as several pesticides, some of which are emerging. The variety of these food contaminants also leads us to consider the role of mixtures, their time and period of exposure and the effect of low doses.