Is tranexamic acid exposure related to blood loss in hip arthroplasty? A pharmacokinetic–pharmacodynamic study

摘要

Aims Tranexamic acid (TXA) is an antifibrinolytic agent, decreasing blood loss in hip arthroplasty. The present study investigated the relationship between TXA exposure markers, including the time above the in vitro threshold reported for inhibition of fibrinolysis (10?mg l ?1 ), and perioperative blood loss. Methods Data were obtained from a prospective, double‐blind, parallel‐arm, randomized superiority study in hip arthroplasty. Patients received a preoperative intravenous bolus of TXA 1?g followed by a continuous infusion of either TXA 1?g or placebo over 8?h. A population pharmacokinetic study was conducted to quantify TXA exposure. Results In total, 827 TXA plasma concentrations were measured in 166 patients. A two‐compartment model fitted the data best, total body weight determining interpatient variability in the central volume of distribution. Creatinine clearance accounted for interpatient variability in clearance. At the end of surgery, all patients had TXA concentrations above the therapeutic target of 10?mg l ?1 . The model‐estimated time during which the TXA concentration was above 10?mg l ?1 ranged from 3.3?h to 16.3?h. No relationship was found between blood loss and either the time during which the TXA concentration exceeded 10?mg l ?1 or the other exposure markers tested (maximum plasma concentration, area under the concentration–time curve). Conclusion In hip arthroplasty, TXA plasma concentrations were maintained above 10?mg l ?1 during surgery and for a minimum of 3?h with a preoperative TXA dose of 1?g. Keeping TXA concentrations above this threshold up to 16?h conferred no advantage with regard to blood loss.