Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib

Mohamed Mohamed-Eslam F.; Jungerwirth Steven; Asatryan Armen; Jiang Ping; Othman Ahmed A.

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Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib

机译：CYP3A抑制，CYP诱导，oATP1B抑制作用和高脂肪膳食对JAK1抑制剂Upadacitinib的药代动力学的评估评估

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《British Journal of Clinical Pharmacology》 |2017年第10期|共7页
作者
Mohamed Mohamed-Eslam F.; Jungerwirth Steven; Asatryan Armen; Jiang Ping; Othman Ahmed A.;
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作者单位

AbbVie Clin Pharmacol &

Pharmacometr 1 North Waukegan Rd Bldg AP31-3 N Chicago IL 60064 USA;

AbbVie Immunol Dev N Chicago IL USA;

AbbVie Immunol Dev N Chicago IL USA;

AbbVie Clin Pharmacol &

Pharmacometr 1 North Waukegan Rd Bldg AP31-3 N Chicago IL 60064 USA;

AbbVie Clin Pharmacol &

Pharmacometr 1 North Waukegan Rd Bldg AP31-3 N Chicago IL 60064 USA;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
high-fat meal; JAK1 inhibitor; ketoconazole; pharmacokinetics; rifampin; upadacitinib;

机译：高脂肪餐;JAK1抑制剂;酮康唑;药代动力学;利福平;upadacitinib;

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1. Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib [J] . Mohamed Mohamed-Eslam F., Jungerwirth Steven, Asatryan Armen, British Journal of Clinical Pharmacology . 2017,第10期

机译：CYP3A抑制，CYP诱导，oATP1B抑制作用和高脂肪膳食对JAK1抑制剂Upadacitinib的药代动力学的评估评估
2. Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib [J] . Mohamed Mohamed-Eslam F., Jungerwirth Steven, Asatryan Armen, British Journal of Clinical Pharmacology . 2017,第10期

机译：CYP3A抑制，CYP诱导，oATP1B抑制作用和高脂肪膳食对JAK1抑制剂Upadacitinib的药代动力学的评估评估
3. Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high‐fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib [J] . Mohamed‐Eslam F. Mohamed, Steven Jungerwirth, Armen Asatryan, British journal of clinical pharmacology . 2017,第10期

机译：评估CYP3A抑制，CYP诱导，OATP1B抑制和高脂膳食对JAK1抑制剂upadacitinib药代动力学的影响
4. Activation of testosterone hydroxylation-the risk for false negatives in the high throughput on-line SPE-MS CYP3A4 inhibition assay [C] . Yongmin Li, Dora Houston, Sam Sperry, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：睾酮羟基激活 - 高通量在线SPE-MS CYP3A4抑制测定中的假焊剂的风险
5. Contribution of itraconazole and its metabolites to in vivo CYP3A4 inhibition. [D] . Templeton, Ian Edward. 2009

机译：伊曲康唑及其代谢物对体内CYP3A4抑制的作用。
6. Assessment of effect of CYP3A inhibition CYP induction OATP1B inhibition and high‐fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib [O] . Mohamed‐Eslam F. Mohamed, Steven Jungerwirth, Armen Asatryan, 2017

机译：评估CYP3A抑制CYP诱导OATP1B抑制和高脂膳食对JAK1抑制剂upadacitinib药代动力学的影响
7. Effects of Strong CYP2C8 or CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Brigatinib, an Oral Anaplastic Lymphoma Kinase Inhibitor, in Healthy Volunteers [O] . Meera Tugnait, Neeraj Gupta, Michael J. Hanley, 2019

机译：强CYP2C8或CYP3A抑制和CYP3A诱导对Brigatinib的药代动力学，口腔血管性淋巴瘤激酶抑制剂，健康志愿者的影响

Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib

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