Synthesis of 2,4-Diaryl-4H-Chromenes via Becarboxylative Alkylation of β-Keto Acids to ortho-Quinone Methides as Eeactive Intermediates

摘要

4H-Chromenes are ubiquitous in natural products and pharmaceuticals with a variety of physiological and biological activities.1 In particular, 2,4-diaryl-4H-chromene moiety forms the core structure of biologically active compounds such as enzyme inhibitors against a variety of targets.2