Application of in vitro CYP and transporter assays to predict clinical drug-drug interactions

Volpe Donna A.; Balimane Praveen V.

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Application of in vitro CYP and transporter assays to predict clinical drug-drug interactions

机译：体外CYP和转运蛋白测定预测临床药物相互作用的应用

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来源
《Bioanalysis》 |2018年第9期|共5页
作者
Volpe Donna A.; Balimane Praveen V.;
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作者单位

US FDA Off Clin Pharmacol Ctr Drug Evaluat &

Res Silver Spring MD 20933 USA;

US FDA Off Clin Pharmacol Ctr Drug Evaluat &

Res Silver Spring MD 20933 USA;

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原文格式 PDF
正文语种 eng
中图分类生物科学;
关键词
drug interactions; drug-metabolizing enzymes; drug transporters; mass spectrometry;

机译：药物相互作用;药物代谢酶;药物转运蛋白;质谱;

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专利

1. Application of in vitro CYP and transporter assays to predict clinical drug-drug interactions [J] . Volpe Donna A., Balimane Praveen V. Bioanalysis . 2018,第9期

机译：体外CYP和转运蛋白测定预测临床药物相互作用的应用
2. A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro. [J] . Fahmi OA, Maurer TS, Kish M, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2008,第8期

机译：一种基于CYP3A4抑制，失活和诱导的体外预测CYP3A4临床净药物相互作用的组合模型。
3. Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction. [J] . Fahmi OA, Hurst S, Plowchalk D Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2009,第8期

机译：基于CYP3A4体外数据的使用，对预测临床药物相互作用的不同算法的比较：化合物作为相互作用的沉淀剂的预测。
4. A Pharmacokinetic Model of Drug-Drug Interaction between Clopidogrel and Omeprazole at CYP 2C19 in Humans [C] . Wimonchat Tangamornsuksan, Pongpak Thiansupornpong, Thirawut Morasuk, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

机译：人类CYP 2C19中氯吡格雷和奥美拉唑与Omeprazole之间的药代动力学模型
5. An in vitro investigation into the mechanism of the clinically relevant drug-drug interaction between omeprazole or esomeprazole and clopidogrel [D] . Ogilvie, Brian Wayne 2015

机译：奥美拉唑或埃索美拉唑与氯吡格雷临床相关药物相互作用机制的体外研究
6. Application of CYP3A4 in vitro data to predict clinical drug–drug interactions; predictions of compounds as objects of interaction [O] . Kuresh A Youdim, Aref Zayed, Maurice Dickins, 2008

机译：CYP3A4体外数据在预测临床药物相互作用中的应用；化合物作为相互作用对象的预测
7. In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters [O] . Diane Ramsden, Jing-Tao Wu, Brad Zerler, 2019

机译：对CYP450酶和转运蛋白的Galnac共轭SIRNA的体外药物 - 药物相互作用评价

Application of in vitro CYP and transporter assays to predict clinical drug-drug interactions

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