A novel urethral sparing technique for high-dose-rate prostate brachytherapy after transurethral resection of the prostate

摘要

Abstract Purpose The purpose of this study was to assess retrospectively the variability of the urethral dose optimized using a Foley catheter versus urethral contrast injected using a new modified triple-lumen catheter, in CT-based high-dose-rate (HDR) prostate brachytherapy of posttransurethral resection of prostate (TURP) patients. Methods and Materials At our institution, there were six post-TURP patients with prostate carcinoma between July 2014 and April 2016 who underwent transperineal interstitial HDR brachytherapy (16 needles). A custom modified triple-lumen catheter was placed to inject contrast into the TURP defect. Three-dimensional optimal plans using inverse planning simulated annealing algorithm was generated according to radiation therapy oncology group dose requirements. Alternative plans were retroactively generated for comparison using standard technique based on a Foley catheter as a urethral constraint volume for each patient with the same weighting factors. We compared the dosimetry parameters in each planning using Wilcoxon's ranked sum nonparametric test. Results The median followup of all patients was 17.5 onths. No significant genitourinary or gastrointestinal toxicity was noted using this technique. In the dosimetric analysis, the prostate V 100 values and TURP urethral V 100 were significantly different between plans with and without the contrast ( V 100 [mean]: 92.4 [%] vs. 94.4 [%], p .046; TURP UV 100 [mean]: 1.4 vs. 2.2, p .028). There were no statistical differences in the mean values of planning target volume V 150 %, V 200 %, and D 90 , and each bladder V 75 and rectum V 75 . Conclusions Post-TURP HDR brachytherapy with urethral contrast showed significantly more volume effect of the TURP defect than that with a Foley catheter alone. Better visualization of the TURP defect should lead to more accurate urethral sparing administration of HDR brachytherapy which is necessary to prevent urethral complication.