A high F-18-FDOPA uptake is associated with a slow growth rate in diffuse Grade II-III gliomas

摘要

Objective: In diffuse Grade II-III gliomas, a high 3,4-dihydroxy-6-(F-18)-fluoro-L-phenylalanine (F-18-FDOPA) positron emission tomography (PET) uptake, with a standardized uptake value (SUVmax)/contralateral brain tissue ratio greater than 1.8, was previously found to be consistently associated with the presence of an isocitrate dehydrogenase (IDH) mutation, whereas this mutation is typically associated with a better prognosis. This pilot study was aimed to ascertain the prognostic value of this high F-18-FDOPA uptake in diffuse Grade II-III gliomas with regard to the velocity of diameter expansion (VDE), which represents an established landmark of better prognosis when below 4mm per year.