A high 18F-FDOPA uptake is associated with a slow growth rate in diffuse Grade II–III gliomas

摘要

Objective:In diffuse Grade II–III gliomas, a high 3,4-dihydroxy-6-(¹⁸F)-fluoro-L-phenylalanine (¹⁸F-FDOPA) positron emission tomography (PET) uptake, with a standardized uptake value (SUVmax)/contralateral brain tissue ratio greater than 1.8, was previously found to be consistently associated with the presence of an isocitrate dehydrogenase (IDH) mutation, whereas this mutation is typically associated with a better prognosis. This pilot study was aimed to ascertain the prognostic value of this high ¹⁸F-FDOPA uptake in diffuse Grade II–III gliomas with regard to the velocity of diameter expansion (VDE), which represents an established landmark of better prognosis when below 4 mm per year.