Quantitative changes in the ageing choriocapillaris as measured by swept source optical coherence tomography angiography

摘要

Aim To analyse quantitative optical coherence tomography angiography (OCTA) parameters of choriocapillaris (CC) at the foveal, perifoveal and parafoveal regions in healthy subjects of different age. Methods In this observational cross-sectional study, consecutive healthy subjects underwent swept source OCTA (PLEX Elite 9000, Carl Zeiss Meditec, USA). 3x3 mm and 6x6 mm scans centred on the fovea were acquired analysed and postprocessed with thresholding and binarisation processes. The main outcome measures included CC quantitative OCTA features (perfusion density (PD), vessel length density (VLD) and vessel diameter index (VDI)) at the foveal, perifoveal and parafoveal regions, and their relationship with age. Results Seventy-two eyes (72 patients, mean age 47.4 +/- 19.2 years, mean axial length 24.0 +/- 0.7 mm) were included. The mean PD was statistically lower in the foveal region compared with the parafoveal region in 3x3 mm scans (p=0.009). In subjects aged 70-80, PD of the foveal region was significantly reduced compared with the perifoveal region in 6x6 mm scans (p=0.008). A strong negative correlation was found between PD and ageing in the foveal, parafoveal and perifoveal regions (p<0.001 in all analyses). Furthermore, PD in the nasal-perifoveal region was significantly lower than the temporal-perifoveal region (p=0.005). No significant correlation was found between VLD and age in all regions, whereas VDI was strictly correlated with age (p<0.001). Conclusions We reported in vivo a strong negative correlation between PD and ageing in the CC of healthy subjects. This reduction seems related to a reduced diameter, and not to a reduced number, of capillaries. The age-related changes were higher in the central area compared with the perifoveal area.