Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome

摘要

Summary We sought to dissect the tumour microenvironment in a small cohort ( N ?=?10) of patients with POEMS at diagnosis and after therapy using mass cytometry. We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45 + and CD3 + compartments. Double positive T cells and PD‐1 positive CD4 T cells were expanded and na?ve CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible antigenic‐driven selection as a driver of disease pathogenesis in POEMS.