A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study

Harbeck Nadia; Saupe Steffen; Jaeger Elke; Schmidt Marcus; Kreienberg Rolf; Mueller Lothar; Otremba Burkhard Joerg; Waldenmaier Dirk; Dorn Julia; Warm Mathias; Scholz Michael; Untch Michael; de Wit Maike; Barinoff Jana; Lueck Hans-Joachim; Harter Philipp; Augustin Doris; Harnett Paul; Beckmann Matthias W.; Al-Batran Salah-Eddin

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A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study

机译：评估聚乙二醇化脂质体DOXORUBICIN与Capecitabine作为转移性乳腺癌的一线治疗的随机阶段III研究：鹈鹕研究的结果

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The PELICAN trial evaluates for the first time efficacy and safety of pegylated liposomal doxorubicin (PLD) versus capecitabine as first-line treatment of metastatic breast cancer (MBC).

机译：鹈鹕试验评估了Pegymated脂质体Doxorubicin（PLD）与Capecitabine作为转移性乳腺癌（MBC）的一线治疗的第一次疗效和安全性。

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《Breast cancer research and treatment. 》 |2017年第1期| 共10页
作者
Harbeck Nadia; Saupe Steffen; Jaeger Elke; Schmidt Marcus; Kreienberg Rolf; Mueller Lothar; Otremba Burkhard Joerg; Waldenmaier Dirk; Dorn Julia; Warm Mathias; Scholz Michael; Untch Michael; de Wit Maike; Barinoff Jana; Lueck Hans-Joachim; Harter Philipp; Augustin Doris; Harnett Paul; Beckmann Matthias W.; Al-Batran Salah-Eddin;
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作者单位

Univ Munich Breast Ctr Dept Obstet &

Gynecol Munich Germany;

Tech Univ Munich Dept Obstet &

Gynecol Munich Germany;

Krankenhaus NW Frankfurt Oncol &

Hematol Frankfurt Germany;

Johannes Gutenberg Univ Mainz Dept Obstet &

Gynecol Mainz Germany;

Univ Frauenklin Ulm Germany;

Onkol Schwerpunktpraxis Leer Germany;

Onkol Praxis Oldenburg Oldenburg Germany;

MSD Sharp &

Dohme Haar Germany;

Tech Univ Munich Dept Obstet &

Gynecol Munich Germany;

Krankenhaus Koln Holweide Brustzentrum Cologne Germany;

Trium Anal Online GmbH Munich Germany;

Helios Klinikum Berlin Buch Berlin Germany;

Vivantes Klinikum Neukoelln Berlin Germany;

Dr Horst Schmidt Kliniken Wiesbaden Wiesbaden Germany;

Dr Horst Schmidt Kliniken Wiesbaden Wiesbaden Germany;

Kliniken Essen Mitte Essen Germany;

Klinikum Landkreises Deggendorf Deggendorf Germany;

Crown Princess Mary Canc Ctr Westmead Sydney NSW Australia;

Univ Hosp Erlangen Comprehens Canc Ctr Erlangen EMN Dept Gynecol &

Obstet Erlangen Germany;

Krankenhaus NW Frankfurt Oncol &

Hematol Frankfurt Germany;

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正文语种 eng
中图分类肿瘤学 ;
关键词
Pegylated liposomal doxorubicin; Capecitabine; Metastatic breast cancer; PELICAN;

机译：聚乙二醇化脂质体DOXORUBICIN;CAPECITABINE;转移性乳腺癌;鹈鹕;

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专利

1. A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study [J] . Harbeck Nadia, Saupe Steffen, Jaeger Elke, Breast cancer research and treatment. . 2017 ,第1期

机译：评估聚乙二醇化脂质体DOXORUBICIN与Capecitabine作为转移性乳腺癌的一线治疗的随机阶段III研究：鹈鹕研究的结果
2. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX(TM)/Doxil((R))) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. [J] . OBrien ME, Wigler N, Inbar M, Annals of oncology: official journal of the European Society for Medical Oncology . 2004 ,第3期

机译：与传统的阿霉素相比，聚乙二醇化脂质体阿霉素HCl（CAELYXTM / Doxil（R））的III期试验具有更低的心脏毒性和相当的疗效，可用于转移性乳腺癌的一线治疗。
3. Cardiotoxicity of a non-pegylated liposomal doxorubicin-based regimen versus an epirubicin-based regimen for breast cancer: The LITE (Liposomal doxorubicin-Investigational chemotherapy-Tissue doppler imaging Evaluation) randomized pilot study [J] . LotrionteM., PalazzoniG., AbbateA., International Journal of Cardiology . 2013 ,第3期

机译：基于非聚乙二醇脂质体的阿霉素方案与基于表柔比星的方案对乳腺癌的心脏毒性：LITE（脂质体阿霉素-研究性化学疗法-组织多普勒成像评估）随机先导研究
4. Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice [C] . Nigel Bush, Andrew Healey, Anant Shah, IEEE International Ultrasonics Symposium . 2019

机译：声学聚类疗法在提高小鼠中提高人类三重阴性乳腺癌的脂质体Doxorubicin治疗的有效性方面的治疗能力
5. Boron Neutron Capture Therapy for HER2+ breast cancers: A feasibility study evaluating BNCT for potential role in breast conservation therapies. [D] . Jenkins, Peter Anthony. 2012

机译：HER2 +乳腺癌的硼中子捕获疗法：评估BNCT在乳腺癌保护疗法中潜在作用的可行性研究。
6. A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study [O] . Nadia Harbeck, Steffen Saupe, Elke Jäger, -1

机译：评价聚乙二醇化脂质体阿霉素和卡培他滨作为转移性乳腺癌的一线治疗的随机III期研究：PELICAN研究的结果
7. A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer : results of the PELICAN study [O] . Harbeck, Nadia, Saupe, Steffen, Jäger, Elke, 2016

机译：评价聚乙二醇化脂质体阿霉素和卡培他滨作为转移性乳腺癌的一线治疗的随机III期研究：PELICAN研究的结果

A randomized phase III study evaluating pegylated liposomal doxorubicin versus capecitabine as first-line therapy for metastatic breast cancer: results of the PELICAN study

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