Use of Inverse Emulsions Based on Siloxanes to Monitor Apparent Diffusion Coefficients in Magnetic Resonance Tomography

摘要

A method for evaluating and standardizing quantitative data for diffusion-weighted (DW) magnetic resonance tomography using a phantom containing an inverse emulsion based on siloxanes is presented. The following characteristics of colloidal systems are addressed: micelle size, chemical phase shifts, proton density, relaxation time, stability, signal intensity on DW images, and the apparent diffusion coefficient (ADC). The use of inverse emulsions based on siloxanes provides for measurement not only of the self-diffusion coefficient, but also restricted diffusion, in the same measurement. The accuracy of measurements of ADC using the samples selected for these studies was assessed by statistical analysis of the distribution of signal intensity and computation of the coefficient of variation.