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Potential new therapies against a toxic relationship: neuroinflammation and Parkinson's disease

机译:潜在的患有毒性关系的新疗法:神经炎症和帕金森病

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Parkinson's disease (PD) is a neurodegenerative disorder classically associated with motor symptoms, but several nonmotor disturbances appear decades before the clinical diagnosis of the disease. A variety of hypotheses exist to explain the onset of PD, and neuroinflammation is one of the most investigated processes. In fact, strong evidence suggests that PD begins with an inflammatory process; currently, however, no anti-inflammatory therapy is clinically employed to alleviate the typical motor and the prodromal disturbances such as olfactory loss, cognitive impairments, depression and anxiety, sleep disturbances, and autonomic disorders. In fact, the classical dopaminergic therapies are not effective in alleviating these symptoms and there is no other specific therapy for these outcomes. Therefore, in this review, we will discuss novel potential pharmacological therapeutic strategies focusing on cannabinoids, caffeine, melatonin, and dietary compounds, which could act as adjuvants to regular PD therapy. These described chemicals have been extensively investigated as anti-inflammatory agents possibly promoting beneficial effects on nonmotor symptoms of PD. The investigation of the inflammatory process at different stages of PD progression should give us a better view of the therapeutic scenario and could improve our understanding of the mechanisms of this disease.
机译:帕金森病(PD)是一种典型与运动症状相关的神经变性障碍,但在疾病的临床诊断前几十年出现了几十年的非等紊乱。存在各种假设来解释Pd的发作,神经炎性是最受研究过程中的一种。实际上,有力的证据表明PD从炎症过程开始;然而,目前,没有抗炎治疗在临床上使用典型的电动机和诸如嗅觉损失,认知障碍,抑郁和焦虑,睡眠障碍和自主主义疾病的前驱紊乱。事实上,古典多巴胺能疗法无效减轻这些症状,并且没有其他特异性治疗这些结果。因此,在本综述中,我们将讨论专注于大麻素,咖啡因,褪黑激素和膳食化合物的新型潜在药理治疗策略,其可作为常规PD治疗的佐剂。这些所描述的化学品已被广泛研究,因为可能促进对Pd的非热源症状的有益作用。 PD进展不同阶段对炎症过程的调查应更好地了解治疗情景,可以改善我们对这种疾病机制的理解。

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