Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedeca-hydro-1,6-naphthyridine-6-carboxyl-ate and (±)-trans-ethyl 2-oxoocta-hydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate

摘要

The chemical scaffolds (1-1), (1-2), (2-1) and (2-2) themselves appear underrepresented in the medicinal chemical literature and therefore warrant further investigation. It had been reported that compound (3) (Scheme 2) targets the bradykinin receptor (Hu et al., 2005), which is a member of the GPCR family and has a key role as a pro-inflammatory mediator (Hall, 1997; Yogi et al., 2009). Compounds (4a) and (4b) (Scheme 2) act as serotonin 5HT receptor ligands (Fevig et al., 2006). The serotonin receptors are found in the central and peripheral nervous system and mediate both excitatory and inhibitory neurotransmission (Wang et al., 2013; Wacker et al., 2013; Raote et al., 2007).