Vielf?ltige Genscheren: natürliche Aktivit?ten von CRISPR-Cas-Systemen

摘要

Prokaryotic genomes often contain CRISPR-Cas systems that enable RNAguided defense against viral attacks. Viral genomes were found to encode anti-CRISPR proteins that inactivate specific Cas protein functions. In the last years, a large variety of CRISPR-Cas system components and mechanisms has been uncovered. This diversity highlights the fact that CRISPRCas systems co-evolve with anti-CRISPR measures, but also indicates that they can adopt roles in the cell that extend beyond viral defense.