Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway

Zhang Hongliang; Wei Xiaojie; Lu Shunyu; Lin Xing; Huang Jianchun; Chen Lixiu; Huang Xiang; Jiang Luhui; Li Yuchun; Qin Luhui; Wei Jinbin; Huang Renbin

首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway

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Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway

机译：DMDD的保护作用，抑制TLR4-BAMBI-SMAD2 / 3信号通路在HK-2细胞中高葡萄糖诱导EMT的高葡萄糖诱导的影响

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Background: Hyperglycemia stimulated epithelial-mesenchymal transition (EMT) plays a critical role in initiating and progressing renal fibrosis in diabetic kidney disease (DKD). It is crucial to explore novel renal protective drugs for the treatment of DKD.

机译：背景：高血糖刺激的上皮 - 间充质转换（EMT）在糖尿病肾病（DKD）中起始和进展肾纤维化中起重要作用。探索用于治疗DKD的新型肾脏保护药是至关重要的。

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《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie》 |2019年第2019期|共9页
作者
Zhang Hongliang; Wei Xiaojie; Lu Shunyu; Lin Xing; Huang Jianchun; Chen Lixiu; Huang Xiang; Jiang Luhui; Li Yuchun; Qin Luhui; Wei Jinbin; Huang Renbin;
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作者单位

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

Guangxi Med Univ Pharmaceut Coll Nanning 530021 Guangxi Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
DMDD; Diabetic kidney disease; epithelial-mesenchymal transition;

机译：DMDD;糖尿病肾病;上皮间充质过渡;

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1. Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway [J] . Zhang Hongliang, Wei Xiaojie, Lu Shunyu, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019,第期

机译：DMDD的保护作用，抑制TLR4-BAMBI-SMAD2 / 3信号通路在HK-2细胞中高葡萄糖诱导EMT的高葡萄糖诱导的影响
2. Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-?oB Signaling Pathway [J] . Qiuqiao Xie, Shijun Zhang, Chunxia Chen, Cellular Physiology and Biochemistry . 2016,第5期

机译：从杨桃中分离得到的2-十二烷基-6-甲氧基环己-2、5-二烯-1、4-二酮对棕榈酸诱导的Min6细胞炎症和凋亡的抑制作用是通过抑制TLR4-MyD88-NF- ？oB信号通路
3. 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from the root of Averrhoa carambola L., protects against diabetic kidney disease by inhibiting TLR4/TGF beta signaling pathway [J] . International immunopharmacology . 2020,第期

机译：2-十二烷基-6-甲氧基己醇-2,5-二烯-1,4-二酮，从Averrhoa阳桃L的根部分离，通过抑制TLR4 / TGFβ信号通路来保护糖尿病肾疾病
4. Conservation and divergence of signalling pathways between roots and soil microbes - the Rhizobium-legume symbiosis compared to the development of lateral roots, mycorrhizal interactions and nematode-induced galls [C] . Ulrike Mathesius Symposium of the International Society of Root Research . 2003

机译：根系和土壤微生物中信号传导途径的保护与分歧 - 与侧根的发育，菌根相互作用和线虫诱导的胆量相比，豆类豆科共生
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway [O] . Luhui Qin, Xiaolin Zhang, Xing Zhou, 2020

机译：苯并醌中抑制TLR4 / NF-κB信号通路中Averrhoa曲棕榈树L.从Averrhoa阳桃糖蛋白诱导的糖尿病小鼠中分离的保护作用
7. >Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway [O] . Luhui Qin, Xiaolin Zhang, Xing Zhou, 2020

机译：>通过抑制TLR4 / NF-κB信号通路，从em> Averrhoa曲棕榈酰氨酰氨酰氨酰氨酰氨酰氨酰突出的糖尿病小鼠诱导糖尿病小鼠的保护作用

Protective effect of DMDD, isolated from the root of Averrhoa carambola L., on high glucose induced EMT in HK-2 cells by inhibiting the TLR4-BAMBI-Smad2/3 signaling pathway

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