Gallic acid protects against bisphenol A-induced alterations in the cardiorenal system of Wistar rats through the antioxidant defense mechanism

摘要

Bisphenol A (BPA) is a small molecular weight endocrine disrupting chemical (EDC) that is used in the production of plastics with deleterious effects on various body systems while gallic acid (GA) is a known antioxidant capable of ameliorating EDC-induced perturbations. In this study, adult male rats (180 +/- 5 g) were divided into four groups of eight rats each: Group A (Control rats): 0.2 ml of corn oil; Group B (GA-treated rats): 20 mg/kg/day GA (dissolved in distilled water); Group C (BPA-treated rats): 10 mg/kg/day BPA suspended in 0.2 ml corn oil; Group D (BPA + GA-treated rats): BPA (10 mg/kg/day) with a concomitant GA (20 mg/kg/day). All treatments were orally administered for 14 days. BPA induced significant decrease in systolic, diastolic and mean arterial blood pressure while causing a significant (p 0.05) increase in heart rate in the rats. It significantly (p 0.05) raised both renal and cardiac reactive oxygen species and depleted the antioxidant system. There were also significant (p 0.05) increases in serum myeloperoxidase, nitric oxide, urea and creatinine in the BPA-treated rats. Lesions of the heart and kidney including inflammation, vascular congestion and erosion of epithelial cells were also observed in the BPA-treated rats. However, the concomitant treatment with GA ameliorated all the BPA-induced alterations of the cardio-renal system. Hence, low dose of GA serves a protective function against BPA-induced toxicity of the heart and kidney.