Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression

Eraky Salma M.; El-Mesery Mohamed; El-Karef Amro; Eissa Laila A.; El-Gayar Amal M.

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Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression

机译：Silymarin和Caffeine组合通过降低LPAR1表达来改善实验诱导的肝纤维化

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Aims: Lysophosphatidic acid is a lipid mediator that is supposed to be implicated in hepatic fibrosis. Silymarin and caffeine are natural compounds known for their anti-inflammatory and antioxidant effects. Our study aimed to explore the effect of silymarin, caffeine, and their combination on lysophosphatidic acid receptor 1 (LPAR1) pathway in thioacetamide (TAA)-induced hepatic fibrosis.

机译：目的：溶血磷脂酸是一种脂质介体，应该涉及肝纤维化。 Silymarin和咖啡因是其抗炎和抗氧化作用所知的天然化合物。我们的研究旨在探讨西米林，咖啡因及其组合对硫代乙酰胺（TAA）诱导的肝纤维化的溶血磷脂酸受体1（LPAR1）途径的影响。

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来源
《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie》 |2018年第2018期|共9页
作者
Eraky Salma M.; El-Mesery Mohamed; El-Karef Amro; Eissa Laila A.; El-Gayar Amal M.;
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作者单位

Mansoura Univ Dept Biochem Fac Pharm Mansoura 35516 Egypt;

Mansoura Univ Dept Biochem Fac Pharm Mansoura 35516 Egypt;

Mansoura Univ Dept Pathol Fac Med Mansoura 35516 Egypt;

Mansoura Univ Dept Biochem Fac Pharm Mansoura 35516 Egypt;

Mansoura Univ Dept Biochem Fac Pharm Mansoura 35516 Egypt;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Caffeine; Connective tissue growth factor; Liver fibrosis; Lysophosphatidic acid receptor 1; Silymarin; Transforming growth factor beta 1;

机译：咖啡因;结缔组织生长因子;肝纤维化;溶血磷脂酸受体1;甲硅烷林;转化生长因子β1;

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1. Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression [J] . Eraky Salma M., El-Mesery Mohamed, El-Karef Amro, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：Silymarin和Caffeine组合通过降低LPAR1表达来改善实验诱导的肝纤维化
2. Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat: possible role in amelioration of insulin resistance and hepatic steatosis. [J] . Yokozawa J, Sasaki T, Ohwada K Journal of gastroenterology . 2009,第6期

机译：肥胖fa / fa Zucker大鼠中血管紧张素II受体阻滞剂对肝硬脂酰辅酶A去饱和酶1表达的下调：在改善胰岛素抵抗和肝脂肪变性中的可能作用。
3. Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat: possible role in amelioration of insulin resistance and hepatic steatosis [J] . Junji Yokozawa, Takashi Sasaki, Kumiko Ohwada, Journal of Gastroenterology . 2009,第6期

机译：肥胖fa / fa Zucker大鼠中血管紧张素II受体阻滞剂对肝硬脂酰辅酶A去饱和酶1表达的下调：在改善胰岛素抵抗和肝脂肪变性中的可能作用
4. Effects of silymarin and pentoxifylline on matrix metalloproteinase-1 and -2 expression and apoptosis in experimental hepatic fibrosis [O] . Eray Kara, Teoman Coşkun, Yavuz Kaya, 2008

机译：水飞蓟素和己酮可可碱对实验性肝纤维化中基质金属蛋白酶-1和-2的表达及细胞凋亡的影响
5. Effects of silymarin and pentoxifylline on matrix metalloproteinase-1 and -2 expression and apoptosis in experimental hepatic fibrosis [O] . Kara Eray, Coşkun Teoman, Kaya Yavuz, 2008

机译：水飞蓟素和己酮可可碱对实验性肝纤维化中基质金属蛋白酶-1和-2的表达及细胞凋亡的影响

Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression

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