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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Analysis of long non-coding RNA and mRNA profiles in epicardial adipose tissue of patients with atrial fibrillation
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Analysis of long non-coding RNA and mRNA profiles in epicardial adipose tissue of patients with atrial fibrillation

机译:心房颤动患者心外膜脂肪组织长期非编码RNA和mRNA谱分析

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摘要

Accumulating studies have suggested that epicardial adipose tissue (EAT) play an important role in the pathogenesis of atrial fibrillation (AF), but few have characterized the underlying mechanism between their interactions. Recent evidence suggested that bioactive molecules secreted from EAT, including exosomes carrying long non-coding RNAs (lncRNAs), may modulate atrial remodeling. LncRNAs are associated with cardiovascular disorders, including AF, but their roles in EAT remain elusive. The aim of the present study was to investigate the expression profile of lncRNAs in EAT with AF. Differentially expressed lncRNAs and nearby mRNAs interaction networks were constructed.
机译:积累研究表明外膜脂肪组织(吃)在心房颤动(AF)的发病机制中发挥着重要作用,但很少有特征在于它们的相互作用之间的潜在机制。 最近的证据表明,从食用中分泌的生物活性分子,包括携带长期非编码RNA(LNCRNA)的外索体,可以调节心房重塑。 LNCRNA与包括AF的心血管障碍有关,但它们在吃的角色仍然难以捉摸。 本研究的目的是研究随着AF的饮食中LNCRNA的表达谱。 构建了差异表达的LNCRNA和附近的MRNAS交互网络。

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