Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine

摘要

BACKGROUND: Benzodiazepines (BZDs) have been used to treat anxiety disorders for more than five decades as the allosteric modulator of the gamma-aminobutyric acid A receptor (GABA(A)R). Little is known about other mechanisms of BZDs. Here, we describe how the rapid stabilization of postsynaptic GABA(A)R is essential and sufficient for the anxiolytic effect of BZDs via a palmitoylation-dependent mechanism.