alpha(1)- and beta(3)-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice

摘要

BACKGROUND: Homeostatic plasticity in mesolimbic dopamine ( DA) neurons plays an essential role in mediating resilience to social stress. Recent evidence implicates an association between stress resilience and projections from the locus coeruleus ( LC) to the ventral tegmental area (VTA) ( LC/VTA) DA system. However, the precise circuitry and molecular mechanisms of the homeostatic plasticity in mesolimbic DA neurons mediated by the LC/VTA circuitry, and its role in conferring resilience to social defeat stress, have not been described.