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The role of necroptosis in cancer: A double-edged sword?

机译:虐疮在癌症中的作用:一把双刃剑吗?

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Necroptosis is a programmed, caspasc-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a potential therapeutic strategy against cancer. Here, we will review the recent research progress of necroptosis in conferring anti- or pro-tumoral effects and its potential application in cancer therapy.
机译:Necroptis是一个编程的Caspasc无关的细胞死亡,其形态学与坏死类似。 与细胞凋亡不同,Necroptis通过释放损伤相关的分子模式引发炎症反应。 最近的研究表明,肿瘤在体内经历了虐余化,死亡疾病在癌症发展和进展中具有抗肿瘤作用。 此外,已探讨肿瘤细胞中的伤害症作为针对癌症的潜在治疗策略。 在这里,我们将审查诸如癌症治疗的抗或促肿瘤效应及其在癌症治疗中的潜在应用中近期的研究进展。

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