A novel chiral electrochemiluminescence sensor that can discriminate proline enantiomers

摘要

A sensitive, stable and stereoselective electrochemiluminescence (ECL) sensor has been designed to enantioselectively discriminate proline enantiomers by immobilizing Ru(bpy)3 ~(2+)-gold nanoparticles (Ru- AuNPs) and b-cyclodextrin-reduced graphene oxide (b-CD-rGO) on glassy carbon electrode. More Ru(bpy)3 ~(2+) could be immobilized on the surface of electrode stably via preparing Ru-AuNPs and better stereoselectivity could be introduced to the sensor via the synthesis of b-CD-rGO. When the developed sensor interacted with proline enantiomers, obvious difference of ECL intensities towards L- and D- proline was observed, and a larger intensity was obtained from D-proline. As a result, ECL technique might act as a promising method to chiral recognition of amino acids enantiomers or chiral drugs.