A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy

Li Jingguo; Zhang Lu; Lin Yujie; Xiao Hong; Zuo Mingxiang; Cheng Du; Shuai Xintao

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A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy

机译：一种pH敏感前药胶束，从多码霉素尾尾聚乙二醇自组装，用于癌症治疗

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A novel tetra-doxorubicin-tailed polyethylene glycol via benzoic-imine bond linkage was synthesized and self-assembled to a pH-sensitive prodrug micelle. This micelle not only effectively entered cancer cells but also quickly released doxorubicin (DOX) in tumor sites to exert anticancer activity in vitro.

机译：通过苯甲酸亚胺键合键合并新的Tetra-Doxorubicin尾聚乙二醇并自组装成pH敏感前药胶束。该胶束不仅有效地进入癌细胞，而且在肿瘤部位中迅速释放了多柔比星（DOX），以在体外发挥抗癌活性。

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来源
《RSC Advances》 |2016年第11期|共4页
作者
Li Jingguo; Zhang Lu; Lin Yujie; Xiao Hong; Zuo Mingxiang; Cheng Du; Shuai Xintao;
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作者单位

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Chem &

Chem Engn Minist Educ PCFM Lab Guangzhou 510275 Guangdong Peoples R China;

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正文语种 eng
中图分类化学;
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1. A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy [J] . Li Jingguo, Zhang Lu, Lin Yujie, RSC Advances . 2016,第11期

机译：一种pH敏感前药胶束，从多码霉素尾尾聚乙二醇自组装，用于癌症治疗
2. pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. [J] . You Qiang Yang, Bin Zhao, Zhen Dong Li, Acta biomaterialia . 2013,第8期

机译：由多臂星形三嵌段共聚物聚（ε-己内酯）-b-聚（甲基丙烯酸2-（二乙氨基）乙酯）-b-聚（聚乙二醇甲基丙烯酸甲酯）自组装而成的pH敏感胶束控制抗癌药物的传递。
3. pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. [J] . You Qiang Yang, Bin Zhao, Zhen Dong Li, Acta biomaterialia . 2013,第8期

机译：pH敏感胶束从多臂恒星三嵌段共聚物自组装，聚合物聚（ε-己内酯）-B-聚（2-（二乙基氨基）乙基丙烯酸甲酯）-B-聚（聚（乙二醇）甲基醚甲基丙烯酸酯）受控抗癌药物递送。
4. Development of High Loading β-Lapachone Prodrug Micelles for NQO1-Specific Cancer Therapy [C] . Xinpeng Ma, Gang Huang, Xiumei Huang, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：用于NQO1特异性癌症治疗的高负荷β-Lapachone前药胶束的开发
5. Mass spectrometric analysis of oligomeric polyethylene glycols, polyethylene glycol monoalkyl ethers, and polyethylene glycol dimethyl ethers. [D] . Onigbinde, Adebayo Omotayo. 1998

机译：低聚聚乙二醇，聚乙二醇单烷基醚和聚乙二醇二甲基醚的质谱分析。
6. Preliminary study on fabrication characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2 [O] . Peng Li, XiaoYue Zhou, Ding Qu, 2017

机译：共价共价共价缀合的Celastol - 聚乙二醇 - 人参醇RH2自组装胶束制备表征和协同抗肺癌作用的初步研究
7. Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer [O] . Wei-liang Ye, Yi-pu Zhao, Huai-qiu Li, 2015

机译：多柔比星 - 聚（乙二醇） - 用于骨转移性癌症的靶向治疗的自组装胶束
8. Chimeric Enzyme/Prodrug Therapy as Novel Gene Therapy for Breast Cancer [R] . Cooper, D. L. 1997

机译：嵌合酶/前药治疗作为乳腺癌的新型基因治疗

A pH-sensitive prodrug micelle self-assembled from multi-doxorubicin-tailed polyethylene glycol for cancer therapy

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