Synthesis of beta-phthalimido-alcohols via regioselective ring opening of epoxide by using reusable basic magnetic nano particles and their biological investigation

摘要

In this work, tetra butyl ammonium hydroxide ([Bu4N]OH) and magnetic nano particles (Fe3O4@SiO2@(CH2)(3)NH2) were introduced as efficient catalysts for the regioselective ring opening of epoxides including aromatic and aliphatic of epoxides to give the corresponding beta-phthalimido-alcohols under mild conditions. A various range of beta-phthalimido-alcohols as new compounds were prepared and fully characterized by IR, H-1 as well as C-13 NMR and mass spectra. Also the synthesized compounds were studied for antioxidant properties by DPPH free radical scavenging assay. The results indicated that studied beta-phthalimido-alcohols derivatives have effective antioxidant functions (IC50: 0.142-0.356 mg mL(-1)) in compare with BHT (IC50: 0.122 mg mL(-1)) and ascorbic acid (IC50: 0.146 mg mL(-1)) as standards. This may be a new health-care food and drug supplement for special use in the future.