A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing

摘要

The nitric oxide/soluble guanylate cyclase/protein kinase G (NO/5GC/PKG) is known to be involved in the regulation of intraocular pressure (IOP) and may be dysregulated. in glaucoma. The purpose is to demonstrate that the 5GC activator MGV354 lowers IOP in a monkey model of glaucoma and could be considered as a possible new clinical drug candidate.