Glycoprotein IIIa gene polymorphism in children with a family history of premature coronary artery disease.

摘要

We read with interest the recent article of Aydmalp et al., who concluded that glycoprotein IIb/IIIa genotype was not shown to be a significant factor in determining the presence of coronary artery disease (CAD) and that there was no correlation between the genotype and plaque vulnerability. Platelet activation and aggregation play a major role in the process of arterial thrombosis and CAD. The platelet surface receptor glycoprotein Ilb/IIIa (GP IIb/IIIa) plays a key role in the formation of thrombus. GP IIIa polymorphism at codon 33 (Leu-33Pro), also known as HPA-1a (P1A1) to HPA-1b (P1A2), has been identified as a risk factor for acute coronary thrombosis. The first report by Weiss et al. suggested an association between P1A2 polymorphism and acute coronary thrombosis. However, these outcomes have not been supported by the other studies.