Synthesis, crystal structures and properties of 1,1′-ferrocenyldi(bisamide) derivatives generated by the double Ugi four-component reaction

摘要

AbstractIn this article, six novel 1,1′-ferrocenyldi(bisamide) derivatives1–6were facilely synthesized in good yieldsviathe double Ugi four-component reaction. Their chemical structures were fully characterized by IR, NMR and HR-MS analyses. The crystal structural evaluation demonstrates that3and5adopt a linear centrosymmetric conformation, while6gives a v-shape conformer in the solid state. They all assemble into 2-D networks and create diverse supramolecular motifs involving 6- to 26-membered rings by combining versatile N?H???O, C?H???O, and C?H???πinteractions. The crystal packing driving forces were further confirmed with the Hirshfeld surface analysis. Moreover, their electrochemical recognition properties were initially assessed. In these 1,1′-ferrocenyldi(bisamide) conjugates, variant substituents at the bisamide chain greatly affect not only the supramolecular assemble but also the electrochemical recognition properties.Graphical abstractDisplay OmittedHighlights?An efficient method for synthesis of 1,1′-ferrocenyl-bisamide conjugates has been developed.?Six novel 1,1′-ferrocenyldi(bisamide) derivatives were facilely synthesized and characterized.?They exhibit diverse intermolecular contacts and supramolecular ring motifs in the solid state.?Their crystal packing driving forces were well identified with the Hirshfeld surface analysis.]]>