Validation of the Stage Groupings in the Eighth Edition of the TNM Classification for Lung Cancer

摘要

Abstract Introduction The aim of this study was to validate stage groupings in the eighth edition of the TNM classification in an independent Chinese cohort. Methods We retrospectively analyzed a total of 3599 patients with pathological stage IA to IIIA (seventh edition of the TNM) NSCLC who underwent surgical treatment in two surgical centers in the People's Republic of China between 2005 and 2012. All patients were reclassified according to the eighth edition of the TNM classification. Survival was compared between adjacent stage groupings by using a log-rank test and燼 Cox regression model. R 2 was calculated to evaluate the燿iscrimination of the two TNM stage classifications. Results The median follow-up time was 48.7 months. According to the eighth edition of the TNM classification, the overall survival (OS) of adjacent stage groupings showed significant differences except for營A3 vs. IB. The eighth edition of the TNM classification yielded a slightly higher R 2 than the seventh edition (0.172 vs. 0.162). Conclusions This study provided an external validation of the stage groupings in the eighth edition of the TNM classification for lung cancer among surgically treated Chinese patients with NSCLC. ]]>