P3.02c-027 Phase I and PK Study of the Folate Receptor-Targeted Small Molecule Drug Conjugate (SMDC) EC1456 in Advanced Cancer: Lung Cancer Subset

Martin Edelman; Jasgit Sachdev; Wael Harb; Allison Armour; Ding Wang; Linda Garland

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P3.02c-027 Phase I and PK Study of the Folate Receptor-Targeted Small Molecule Drug Conjugate (SMDC) EC1456 in Advanced Cancer: Lung Cancer Subset

机译：P3.02C-027期I和PK研究叶酸受体靶向小分子药物缀合物（SMDC）EC1456在晚期癌症中：肺癌子集

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来源
《Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer》 |2017年第1期|共2页
作者
Martin Edelman; Jasgit Sachdev; Wael Harb; Allison Armour; Ding Wang; Linda Garland;
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作者单位

Greenebaum Cancer Center University of Maryland;

Virginia Piper Cancer Center;

Horizon Cancer Center;

Endocyte;

Josephine Ford Cancer Institute;

University of Arizona;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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1. P3.02c-027 Phase I and PK Study of the Folate Receptor-Targeted Small Molecule Drug Conjugate (SMDC) EC1456 in Advanced Cancer: Lung Cancer Subset [J] . Martin Edelman, Jasgit Sachdev, Wael Harb, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2017,第1期

机译：P3.02C-027期I和PK研究叶酸受体靶向小分子药物缀合物（SMDC）EC1456在晚期癌症中：肺癌子集
2. Development and validation of a UPLC-MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice [J] . Rao Satish I., Pugh Michael, Nelson Melissa, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2016,第Null期

机译：新型叶酸靶向小分子药物偶联物EC1456及其代谢物在小鼠肿瘤匀浆中的UPLC-MS / MS方法开发和验证
3. AZD8186 study 1: Phase I study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary anti-tumour activity of AZD8186 in patients with advanced castration resistant prostate cancer (CRPC), squamous non-small cell lung cancer, triple negative breast cancer and with PTEN-deficient/mutated or PIK3CB mutated/amplified malignancies, as monotherapy and in combination with vistusertib (AZD2014) or abiraterone acetate [J] . Lillian S., De Bono J., Higano C., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016,第Null期

机译：AZD8186研究1：I期研究评估AZD8186在晚期去势抵抗性前列腺癌（CRPC），鳞状非小细胞肺癌患者中的安全性，耐受性，药代动力学（PK），药效学（PD）和初步抗肿瘤活性，三联阴性乳腺癌以及PTEN缺陷/突变或PIK3CB突变/扩增的恶性肿瘤，单药治疗并与vistusertib（AZD2014）或醋酸阿比特龙合用
4. Folate Conjugated Poly(ester amine) for Lung Cancer Therapy [C] . Myunq Hainq Cho, Rohidas Arote, Soon Kyung Hwang, Controlled Release Society Annual Meeting and Exposition . 2007

机译：叶酸共轭聚（酯胺）在肺癌治疗中的作用
5. Design and Evaluation of Peptidomimetics and Peptidomimetics Drug Conjugates Targeting HER2 Overexpressing Cells in Breast and Lung Cancers [D] . Pallerla, Sandeep. 2017

机译：拟肽和拟肽药物结合物靶向乳腺癌和肺癌中HER2过表达细胞的设计和评估
6. A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase [O] . Andrew Michael Beekman, Marco M. D. Cominetti, Oliver Charles Cartwright, 2019

机译：Dupa的小分子药物缀合物（SMDC）和在固相上建立的一臂
7. 138 Phase 1 dose-escalation study of STRO-002, an anti-folate receptor alpha (FRα) antibody drug conjugate (ADC), in patients with advanced platinum-resistant/refractory epithelial ovarian cancer (OC) [O] . R Naumann, F Braiteh, J Diaz, 2020

机译：138阶段1剂量 - 抗叶酸受体α（FRα）抗体药物缀合物（ADC）的抗叶酸受体α（FRα）抗体药物缀合物（ADC），抑制铂抗性/难治性上皮卵巢癌（OC）

P3.02c-027 Phase I and PK Study of the Folate Receptor-Targeted Small Molecule Drug Conjugate (SMDC) EC1456 in Advanced Cancer: Lung Cancer Subset

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