首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests
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Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests

机译:同时评估多系统萎缩和皮质小脑萎缩与计算机触摸面板筛选试验相关的认知和情感功能

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Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n = 25), MSA with predominant parkinson-ism (MSA-P, n = 8), and CCA (n = 14) patients using computerized touch panel screening tests. Mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), frontal assessment battery (FAB), and Montreal cognitive assessment (MoCA) scores were significantly lower in MSA-C patients than in age-and gender-matched normal controls. One MSA-C patient showed a decrease in the regional cerebral blood flow (rCBF) of the frontal lobe. MSA-P patients showed no such cognitive decline. Only FAB and MoCA scores were significantly lower in the CCA patients. MSA and CCA patients also showed a mild to moderate depressive state. Touch-panel screening tests demonstrated a significant decline of beating devils game in all three disease groups including MSA-P patients, and a significant extension of the flipping cards game only in MSA-C patients. The present study demonstrated different cognitive and affective functions among MSA-C, MSA-P, and CCA patients, and a sensitive screening method for cognitive assessment using touch-panel tests.
机译:多系统萎缩(MSA)和皮质小脑萎缩(CCA)的认知损伤和情感功能障碍尚未同时检查了标准测试电池和敏感工具以检测患者微妙的认知下降。在本研究中,我们在MSA中同时检查了MSA的认知和情感能力,具有主要的小脑共济失调(MSA-C,N = 25),MSA具有主要帕金森 - ISM(MSA-P,N = 8)和CCA(n = 14 )使用计算机化触摸板筛选测试的患者。 MSA-C患者的迷你精神状态检查(MMSE),HAPEGAWA痴呆规模规模(HDS-R),正面评估电池(MOCA)分数明显低于年龄 - 和性别 - 匹配的正常控制。一个MSA-C患者显示额叶的区域脑血流(RCBF)降低。 MSA-P患者显示没有这种认知下降。 CCA患者只有Fab和Moca评分显着降低。 MSA和CCA患者也表现出一种温和至中度抑郁状态。触摸面板筛选试验表明,在包括MSA-P患者的所有三种疾病群中,击败魔鬼游戏的显着下降,以及仅在MSA-C患者中的翻转卡游戏的重要延伸。本研究表明了MSA-C,MSA-P和CCA患者中的不同认知和情感功能,以及使用触摸板测试的认知评估的敏感筛选方法。

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