Editorial: Targeting the IGF-I Receptor Signaling Pathway: Implications for Human Cancer Therapy

摘要

A common molecular abnormality in human cancer is the presence of multiple autocrine loops, with one of the most prominent involving co-expression of insulin-like growth factor-I (IGF-I) and its receptor. Epidemiological studies have shown that increased serum levels of IGF-I and decreased levels of its predominant binding protein, IGFBP-3, correlate with an increased risk for several types of cancers. IGF-I has also been shown to be an important regulator of VEGF expression and angiogenesis in several cancers. In writing this review issue, we have sought to provide an updated overview on the role of IGFs and the IGF-I receptor signaling pathway in human cancer