A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids

摘要

Ethnopharmacological relevance: The herbs of Aconitum are the essential Traditional Chinese medicine and have played an indispensable role in many Asian countries for thousands of years to treat critical illnesses, and chronic, stubborn diseases. However, Aconitum may induce severe neurotoxicity and even death. So far the mechanism of Aconitum penetrating the blood -brain barrier (BBB) is still unclear.