Dehydropachymic acid decreases bafilomycin A1 induced beta-Amyloid accumulation in PC12 cells

Yu Mengyao; Xu Xiaoyan; Jiang Nan; Wei Wei; Li Fang; He Liming; Luo Xia

首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Dehydropachymic acid decreases bafilomycin A1 induced beta-Amyloid accumulation in PC12 cells

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Dehydropachymic acid decreases bafilomycin A1 induced beta-Amyloid accumulation in PC12 cells

机译：脱氢酸可降低BafiLomycin A1在PC12细胞中诱导的β-淀粉样蛋白积累

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摘要

Ethnopharmacological relevance: Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. However, its mechanisms on prevention and treatment of AD have not been well elucidated yet.

机译：民族科医生相关性：茯苓的核心菌，茯苓菌，经常用于过去10世纪的中药（AD）干预的中药（TCM）公式。其提取物在先前研究中的AD细胞和动物模型中表现出显着的影响。然而，它的预防和治疗广告的机制尚未得到很好的阐明。

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来源
《Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 |2017年第2017期|共7页
作者
Yu Mengyao; Xu Xiaoyan; Jiang Nan; Wei Wei; Li Fang; He Liming; Luo Xia;
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作者单位

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

Sichuan Acad Chinese Med Sci 51 4th Sect South Renmin Rd Chengdu 610041 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Alzheimer's disease; Dehydropachymic acid; Autophagy; Lysosome; beta-amyloid; Bafilomycin A1;

机译：阿尔茨海默病;脱氢化酸;自噬;溶酶体;β-淀粉样蛋白;Bafileomycin A1;

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专利

1. Dehydropachymic acid decreases bafilomycin A1 induced beta-Amyloid accumulation in PC12 cells [J] . Yu Mengyao, Xu Xiaoyan, Jiang Nan, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2017,第期

机译：脱氢酸可降低BafiLomycin A1在PC12细胞中诱导的β-淀粉样蛋白积累
2. Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH [J] . Kinoshita Kuninori, Minemoto Yuzuru, Nishikawa Yasuko, FEBS Letters . 1996,第1期

机译：Bafilomycin A1独立于细胞内pH诱导PC12细胞凋亡
3. Trans Fatty Acids Enhanced Beta-Amyloid Induced Oxidative Stress in Nerve Growth Factor Differentiated PC12 Cells [J] . Shih-jei Tsai, Wen-hu Liu, Mei-chin Yin Neurochemical Research . 2012,第4期

机译：反式脂肪酸增强神经生长因子分化PC12细胞中β-淀粉样蛋白诱导的氧化应激。
4. Influence of serum proteins on the accumulation of aminolaevulinic acid-induced protoporphyrin IX in cells in culture [C] . M.M. Weir, Univ. of Leeds, Leeds, 5th International Photodynamic Association Biennial Meeting . 1995

机译：血清蛋白对氨基油蛋白诱导的原卟啉在培养细胞中积累的影响
5. Neuroprotective effects of antioxidants, Idebenone and Ferulic Acid, in MPP(+)-induced PC12 cells, as a model of Parkinson's disease. [D] . Gupta, Shilpi. 2013

机译：抗氧化剂，艾地苯醌和阿魏酸在MPP（+）诱导的PC12细胞中的神经保护作用，作为帕金森氏病的模型。
6. Modification by brefeldin A bafilomycin A1 and 7-chloro-4-nitrobenz-2-oxa-13-diazole (NBD) of cellular accumulation and intracellular distribution of anthracyclines in the non-P-glycoprotein-mediated multidrug-resistant cell line COR-L23/R. [O] . T. Rhodes, M. A. Barrand, P. R. Twentyman 1994

机译：布雷菲德菌素A巴氟霉素A1和7-氯-4-硝基苯-2-恶唑-13-二唑（NBD）对非P-糖蛋白介导的多药耐药细胞系中蒽环类药物细胞积累和细胞内分布的修饰COR-L23 / R。
7. Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH [O] . Kinoshita Kuninori, Waritani Takaki, Noto Masahiko, 1996

机译：Bafilomycin A1诱导PC12细胞凋亡，独立于细胞内pH
8. Botulinum Toxin Type A Targets RhoB to Inhibit Lysophosphatidic Acid- Stimulated Actin Reorganization and Acetylcholine Release in PC12 Cells: A Possible Mechanism For Intervention [R] . Ishida, H. , Liao, Z. , Ray, P. 2004

机译：a型肉毒毒素靶向RhoB抑制溶血磷脂酸刺激的pC12细胞中肌动蛋白重组和乙酰胆碱释放：一种可能的干预机制

Dehydropachymic acid decreases bafilomycin A1 induced beta-Amyloid accumulation in PC12 cells

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